DegronMD

Uniprot ID: O60828

Source protein: Polyglutamine-binding protein 1

Source gene: PQBP1

Class: DEG_APCC_DBOX_1

Location: 13:21

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8196

ASA_SCORE: 95.9556

COIL: 0.8079

CONS_SCORE: 0.6283

DSS_SCORE: 0.3906

HELIX: 0.1449

FCONS_SCORE: 0.9548

RIG_SCORE: 0.7344

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E31K	TCGA-43-A475	LUSC	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	0.0556
p.E31K	TCGA-BR-8487	STAD	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	0.0556
p.E31K	DO45431	LUSC	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	0.0556
p.E31K	DO47867	STAD	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	0.0556
p.E21D	TCGA-BS-A0UF	UCEC	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	0.5647
p.E21D	DO41488	UCEC	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	0.5647
p.L20M	TCGA-BS-A0UV	UCEC	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	0.5999
p.L20M	DO42793	UCEC	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	0.5999
p.E27D	TCGA-E6-A1LX	UCEC	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	0.1667
p.E27D	DO41020	UCEC	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	0.1667
p.P4H	TCGA-EE-A3AC	SKCM	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	0.0833
p.P4H	DO37631	SKCM	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	0.0833
p.A30V	TCGA-EO-A22U	UCEC	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	0.0833
p.A30V	DO43755	UCEC	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	0.0833
p.R10H	TCGA-FI-A2D5	UCEC	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	0.25
p.R10H	DO41331	UCEC	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	0.25
p.E27Q	TCGA-JW-A5VL	CESC	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	0.1667
p.E27Q	DO49976	CESC	ICGC	KRGILKHLE	DEG_APCC_DBOX_1	0.1667
p.E21K	TCGA-L5-A8NT	ESCA	TCGA	KRGILKHLE	DEG_APCC_DBOX_1	0.591
p.A12T	ACH-002664	Colon/Colorectal Cancer	CCLE	KRGILKHLE	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60828	Polyglutamine-binding protein 1	DEG_APCC_DBOX_1	13:21	KRGILKHLE	APC,CDC20,FZR1	0.8196	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons