DegronMD

Uniprot ID: Q8NE62

Source protein: Choline dehydrogenase, mitochondrial

Source gene: CHDH

Class: DEG_SIAH_1

Location: 523:531

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.6456

ASA_SCORE: 45.6667

COIL: 0.6963

CONS_SCORE: 0.6174

DSS_SCORE: 0.4734

HELIX: 0.1642

FCONS_SCORE: 0.8829

RIG_SCORE: 0.7572

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M518T	TCGA-AX-A0J0	UCEC	TCGA	DPTAVVDPQ	DEG_SIAH_1	0.1944
p.M518T	DO41133	UCEC	ICGC	DPTAVVDPQ	DEG_SIAH_1	0.1944
p.E538K	TCGA-GN-A266	SKCM	TCGA	DPTAVVDPQ	DEG_SIAH_1	0.1389
p.E538K	DO37432	SKCM	ICGC	DPTAVVDPQ	DEG_SIAH_1	0.1389
p.V528A	DO233179	GACA	ICGC	DPTAVVDPQ	DEG_SIAH_1	0.6936
p.P524H	DO229037	LICA	ICGC	DPTAVVDPQ	DEG_SIAH_1	0.7694
p.V537L	DO221123	MALY	ICGC	DPTAVVDPQ	DEG_SIAH_1	0.1667
p.P521S	DO229494	SKCA	ICGC	DPTAVVDPQ	DEG_SIAH_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NE62	Choline dehydrogenase, mitochondrial	DEG_SIAH_1	523:531	DPTAVVDPQ	SIAH1,SIAH2,SIAH3	0.6456	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons