DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
DPYTAAP
Uniprot ID:
Q7Z5L3
Source protein:
Complement C1q-like protein 2
Source gene:
C1QL2
Class:
CBL_PTK
Location:
34:40
E3 ligase:
CBL
DEGRON score:
0.9149
ASA_SCORE:
65.9429
COIL:
0.8757
CONS_SCORE:
0.3086
DSS_SCORE:
0.3755
HELIX:
0.0583
FCONS_SCORE:
1.0524
RIG_SCORE:
0.7038
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.M25I
TCGA-FD-A5BV
BLCA
TCGA
DPYTAAP
CBL_PTK
0.0833
p.M25I
DO44036
BLCA
ICGC
DPYTAAP
CBL_PTK
0.0833
p.G41C
DO223509
CLLE
ICGC
DPYTAAP
CBL_PTK
0.3056
p.P35T
DO229045
LICA
ICGC
DPYTAAP
CBL_PTK
0.5919
p.Y36C
DO23104
LINC
ICGC
DPYTAAP
CBL_PTK
0.7087
p.E24Q
ACH-002669
Colon/Colorectal Cancer
CCLE
DPYTAAP
CBL_PTK
0.0556
Drug responses associated with C1QL2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DPYTAAP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z5L3
Complement C1q-like protein 2
CBL_PTK
34:40
DPYTAAP
CBL
0.9149
More...
