DegronMD - Q7Z5L3(C1QL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D287G	TCGA-AA-A00N	COAD	TCGA	FLLYPD	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.7198
p.D287G	DO9876	COAD	ICGC	FLLYPD	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.7198
p.N273D	TCGA-CV-A45Z	HNSC	TCGA	FLLYPD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.N273D	DO52064	HNSC	ICGC	FLLYPD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.E107A	TCGA-DD-AAE3	LIHC	TCGA	GRPGLPGLQ	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.1944
p.E107A	DO52258	LIHC	ICGC	GRPGLPGLQ	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.1944
p.M25I	TCGA-FD-A5BV	BLCA	TCGA	DPYTAAP	CBL_PTK	34:40	Mutation rewiring degron network	0.0833
p.M25I	DO44036	BLCA	ICGC	DPYTAAP	CBL_PTK	34:40	Mutation rewiring degron network	0.0833
p.F282Y	TCGA-GN-A4U7	SKCM	TCGA	FLLYPD	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.7528
p.F282Y	DO51258	SKCM	ICGC	FLLYPD	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.7528
p.N274K	TCGA-NC-A5HO	LUSC	TCGA	FLLYPD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1111
p.N274K	DO219197	LUSC	ICGC	FLLYPD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1111
p.G41C	DO223509	CLLE	ICGC	DPYTAAP	CBL_PTK	34:40	Mutation rewiring degron network	0.3056
p.P35T	DO229045	LICA	ICGC	DPYTAAP	CBL_PTK	34:40	Mutation altering degron motif	0.5919
p.Y36C	DO23104	LINC	ICGC	DPYTAAP	CBL_PTK	34:40	Mutation altering degron motif	0.7087
p.D110N	DO38727	STAD	ICGC	GRPGLPGLQ	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.2778
p.K108E	DO229272	THCA	ICGC	GRPGLPGLQ	DEG_APCC_DBOX_1	112:120	Mutation substituting flanking lysine	0.3333
p.Y285C	SIDM00151	Ovarian Carcinoma	GDSC	FLLYPD	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.7087
p.Y285C	ACH-000966	Ovarian Cancer	CCLE	FLLYPD	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.7087
p.Y285C	IGROV-1	ovary	COSMIC	FLLYPD	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.7087
p.A126T	SIDM00068	Colorectal Carcinoma	GDSC	GRPGLPGLQ	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.1667
p.Y276H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	FLLYPD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1667
p.Y276H	ACH-000937	Leukemia	CCLE	FLLYPD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1667
p.Y276H	PF-382	haematopoietic and lymphoid tissue	COSMIC	FLLYPD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1667
p.G130R	ACH-000937	Leukemia	CCLE	GRPGLPGLQ	DEG_APCC_DBOX_1	112:120	Mutation rewiring degron network	0.0556
p.E24Q	ACH-002669	Colon/Colorectal Cancer	CCLE	DPYTAAP	CBL_PTK	34:40	Mutation rewiring degron network	0.0556

Kaplan plot for C1QL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C1QL2

UniProt ID: Q7Z5L3

Entrez ID: 165257

Protein name: Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C1QL2 in