DegronMD

Uniprot ID: Q7Z5L3

Source protein: Complement C1q-like protein 2

Source gene: C1QL2

Class: DEG_APCC_DBOX_1

Location: 112:120

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8533

ASA_SCORE: 69.8222

COIL: 0.8733

CONS_SCORE: 0.413

DSS_SCORE: 0.7645

HELIX: 0.0687

FCONS_SCORE: 0.9797

RIG_SCORE: 0.6294

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E107A	TCGA-DD-AAE3	LIHC	TCGA	GRPGLPGLQ	DEG_APCC_DBOX_1	0.1944
p.E107A	DO52258	LIHC	ICGC	GRPGLPGLQ	DEG_APCC_DBOX_1	0.1944
p.D110N	DO38727	STAD	ICGC	GRPGLPGLQ	DEG_APCC_DBOX_1	0.2778
p.K108E	DO229272	THCA	ICGC	GRPGLPGLQ	DEG_APCC_DBOX_1	0.3333
p.A126T	SIDM00068	Colorectal Carcinoma	GDSC	GRPGLPGLQ	DEG_APCC_DBOX_1	0.1667
p.G130R	ACH-000937	Leukemia	CCLE	GRPGLPGLQ	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5L3	Complement C1q-like protein 2	DEG_APCC_DBOX_1	112:120	GRPGLPGLQ	APC,CDC20,FZR1	0.8533	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons