DegronMD

Uniprot ID: Q7Z5L3

Source protein: Complement C1q-like protein 2

Source gene: C1QL2

Class: LIG_APCC_ABBA_1

Location: 282:287

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6166

ASA_SCORE: 57.6333

COIL: 0.4508

CONS_SCORE: 0.5986

DSS_SCORE: 0.6129

HELIX: 0.0047

FCONS_SCORE: 0.893

RIG_SCORE: 0.8279

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D287G	TCGA-AA-A00N	COAD	TCGA	FLLYPD	LIG_APCC_ABBA_1	0.7198
p.D287G	DO9876	COAD	ICGC	FLLYPD	LIG_APCC_ABBA_1	0.7198
p.N273D	TCGA-CV-A45Z	HNSC	TCGA	FLLYPD	LIG_APCC_ABBA_1	0.0833
p.N273D	DO52064	HNSC	ICGC	FLLYPD	LIG_APCC_ABBA_1	0.0833
p.F282Y	TCGA-GN-A4U7	SKCM	TCGA	FLLYPD	LIG_APCC_ABBA_1	0.7528
p.F282Y	DO51258	SKCM	ICGC	FLLYPD	LIG_APCC_ABBA_1	0.7528
p.N274K	TCGA-NC-A5HO	LUSC	TCGA	FLLYPD	LIG_APCC_ABBA_1	0.1111
p.N274K	DO219197	LUSC	ICGC	FLLYPD	LIG_APCC_ABBA_1	0.1111
p.Y285C	SIDM00151	Ovarian Carcinoma	GDSC	FLLYPD	LIG_APCC_ABBA_1	0.7087
p.Y285C	ACH-000966	Ovarian Cancer	CCLE	FLLYPD	LIG_APCC_ABBA_1	0.7087
p.Y285C	IGROV-1	ovary	COSMIC	FLLYPD	LIG_APCC_ABBA_1	0.7087
p.Y276H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	FLLYPD	LIG_APCC_ABBA_1	0.1667
p.Y276H	ACH-000937	Leukemia	CCLE	FLLYPD	LIG_APCC_ABBA_1	0.1667
p.Y276H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	FLLYPD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5L3	Complement C1q-like protein 2	LIG_APCC_ABBA_1	282:287	FLLYPD	APC,CDC20,FZR1	0.6166	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons