DegronMD

Uniprot ID: Q9NXH9

Source protein: tRNA

Source gene: TRMT1

Class: CBL_PTK

Location: 618:626

E3 ligase: CBL

DEGRON score: 0.8787

ASA_SCORE: 62.0222

COIL: 0.5744

CONS_SCORE: 0.1411

DSS_SCORE: 0.3099

HELIX: 0.0483

FCONS_SCORE: 1.0949

RIG_SCORE: 0.6793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R616C	TCGA-BG-A222	UCEC	TCGA	DQCCYSHSP	CBL_PTK	0.2778
p.R616C	DO42977	UCEC	ICGC	DQCCYSHSP	CBL_PTK	0.2778
p.Q619P	SIDM00958	Chronic Myelogenous Leukemia	GDSC	DQCCYSHSP	CBL_PTK	0.5924
p.Q619P	ACH-000920	Leukemia	CCLE	DQCCYSHSP	CBL_PTK	0.5924
p.Q619P	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DQCCYSHSP	CBL_PTK	0.5924
p.T617S	EVSA-T	breast	COSMIC	DQCCYSHSP	CBL_PTK	0.3056
p.P611L	SNU-C2B	large_intestine	COSMIC	DQCCYSHSP	CBL_PTK	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXH9	tRNA	CBL_PTK	618:626	DQCCYSHSP	CBL	0.8787	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons