DegronMD - Q9NXH9(TRMT1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R616C	TCGA-BG-A222	UCEC	TCGA	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.0556
p.R616C	TCGA-BG-A222	UCEC	TCGA	DQCCYSHSP	CBL_PTK	618:626	Mutation rewiring degron network	0.2778
p.R616C	DO42977	UCEC	ICGC	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.0556
p.R616C	DO42977	UCEC	ICGC	DQCCYSHSP	CBL_PTK	618:626	Mutation rewiring degron network	0.2778
p.R630M	TCGA-EE-A29X	SKCM	TCGA	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation altering degron motif	0.7521
p.R630M	DO37595	SKCM	ICGC	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation altering degron motif	0.7521
p.P627S	DO222868	MELA	ICGC	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation altering degron motif	0.5641
p.P640L	SIDM00781	Colorectal Carcinoma	GDSC	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.1111
p.P640L	SIDM00780	Colorectal Carcinoma	GDSC	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.1111
p.P640L	ACH-000967	Colon/Colorectal Cancer	CCLE	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.1111
p.P640L	ACH-001199	Colon/Colorectal Cancer	CCLE	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.1111
p.P640L	SNU-C2B	large intestine	COSMIC	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.1111
p.Q619P	SIDM00958	Chronic Myelogenous Leukemia	GDSC	DQCCYSHSP	CBL_PTK	618:626	Mutation altering degron motif	0.5924
p.Q619P	ACH-000920	Leukemia	CCLE	DQCCYSHSP	CBL_PTK	618:626	Mutation altering degron motif	0.5924
p.Q619P	CML-T1	haematopoietic and lymphoid tissue	COSMIC	DQCCYSHSP	CBL_PTK	618:626	Mutation altering degron motif	0.5924
p.T642I	SIDM00752	Non-Cancerous	GDSC	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.0556
p.T642I	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.0556
p.T642I	ACH-000904	Lung Cancer	CCLE	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.0556
p.T642I	ACH-002365	Non-Cancerous	CCLE	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.0556
p.T628I	SIDM00045	Gastric Carcinoma	GDSC	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation altering degron motif	0.8189
p.T628I	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation altering degron motif	0.8189
p.T628I	SIDM01612	Endometrial Carcinoma	GDSC	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation altering degron motif	0.8189
p.T628I	RC-K8	haematopoietic and lymphoid tissue	COSMIC	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation altering degron motif	0.8189
p.T628I	HSC-39	stomach	COSMIC	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation altering degron motif	0.8189
p.T617S	EVSA-T	breast	COSMIC	PPTPRVS	DEG_SCF_FBW7_1	626:632	Mutation rewiring degron network	0.0833
p.T617S	EVSA-T	breast	COSMIC	DQCCYSHSP	CBL_PTK	618:626	Mutation rewiring degron network	0.3056
p.P611L	SNU-C2B	large intestine	COSMIC	DQCCYSHSP	CBL_PTK	618:626	Mutation rewiring degron network	0.1389

Kaplan plot for TRMT1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRMT1

UniProt ID: Q9NXH9

Entrez ID: 55621

Protein name: tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TRMT1 in