DegronMD

Uniprot ID: Q9NXH9

Source protein: tRNA

Source gene: TRMT1

Class: DEG_SCF_FBW7_1

Location: 626:632

E3 ligase: FBXW7

DEGRON score: 0.9967

ASA_SCORE: 81.6286

COIL: 0.9426

CONS_SCORE: 0.1108

DSS_SCORE: 0.4193

HELIX: 0.019

FCONS_SCORE: 0.9349

RIG_SCORE: 0.6318

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R616C	TCGA-BG-A222	UCEC	TCGA	PPTPRVS	DEG_SCF_FBW7_1	0.0556
p.R616C	DO42977	UCEC	ICGC	PPTPRVS	DEG_SCF_FBW7_1	0.0556
p.R630M	TCGA-EE-A29X	SKCM	TCGA	PPTPRVS	DEG_SCF_FBW7_1	0.7521
p.R630M	DO37595	SKCM	ICGC	PPTPRVS	DEG_SCF_FBW7_1	0.7521
p.P627S	DO222868	MELA	ICGC	PPTPRVS	DEG_SCF_FBW7_1	0.5641
p.P640L	SIDM00781	Colorectal Carcinoma	GDSC	PPTPRVS	DEG_SCF_FBW7_1	0.1111
p.P640L	SIDM00780	Colorectal Carcinoma	GDSC	PPTPRVS	DEG_SCF_FBW7_1	0.1111
p.P640L	ACH-000967	Colon/Colorectal Cancer	CCLE	PPTPRVS	DEG_SCF_FBW7_1	0.1111
p.P640L	ACH-001199	Colon/Colorectal Cancer	CCLE	PPTPRVS	DEG_SCF_FBW7_1	0.1111
p.P640L	SNU-C2B	large_intestine	COSMIC	PPTPRVS	DEG_SCF_FBW7_1	0.1111
p.T642I	SIDM00752	Non-Cancerous	GDSC	PPTPRVS	DEG_SCF_FBW7_1	0.0556
p.T642I	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PPTPRVS	DEG_SCF_FBW7_1	0.0556
p.T642I	ACH-000904	Lung Cancer	CCLE	PPTPRVS	DEG_SCF_FBW7_1	0.0556
p.T642I	ACH-002365	Non-Cancerous	CCLE	PPTPRVS	DEG_SCF_FBW7_1	0.0556
p.T628I	SIDM00045	Gastric Carcinoma	GDSC	PPTPRVS	DEG_SCF_FBW7_1	0.8189
p.T628I	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPRVS	DEG_SCF_FBW7_1	0.8189
p.T628I	SIDM01612	Endometrial Carcinoma	GDSC	PPTPRVS	DEG_SCF_FBW7_1	0.8189
p.T628I	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPRVS	DEG_SCF_FBW7_1	0.8189
p.T628I	HSC-39	stomach	COSMIC	PPTPRVS	DEG_SCF_FBW7_1	0.8189
p.T617S	EVSA-T	breast	COSMIC	PPTPRVS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXH9	tRNA	DEG_SCF_FBW7_1	626:632	PPTPRVS	FBXW7	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons