DegronMD

Uniprot ID: Q7Z4V5

Source protein: Hepatoma-derived growth factor-related protein 2

Source gene: HDGFL2

Class: DEG_SCF_SKP2-CKS1_1

Location: 201:208

E3 ligase: SKP2,CSK1

DEGRON score: 0.9975

ASA_SCORE: 100.9125

COIL: 0.6739

CONS_SCORE: 0.4686

DSS_SCORE: 0.7284

HELIX: 0.3144

FCONS_SCORE: 1.132

RIG_SCORE: 0.6494

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P215S	SIDM00420	Bladder Carcinoma	GDSC	DQDFTPEK	DEG_SCF_SKP2-CKS1_1	0.1389
p.R216Q	SIDM00596	Endometrial Carcinoma	GDSC	DQDFTPEK	DEG_SCF_SKP2-CKS1_1	0.1111
p.R216Q	HEC-1	endometrium	COSMIC	DQDFTPEK	DEG_SCF_SKP2-CKS1_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SCF_SKP2-CKS1_1	201:208	DQDFTPEK	SKP2,CSK1	0.9975	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons