DegronMD

Uniprot ID: Q6UB99

Source protein: Ankyrin repeat domain-containing protein 11

Source gene: ANKRD11

Class: DEG_APCC_DBOX_1

Location: 1831:1839

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9799

ASA_SCORE: 88.6222

COIL: 0.9492

CONS_SCORE: 0.3394

DSS_SCORE: 0.5287

HELIX: 0.0392

FCONS_SCORE: 0.9045

RIG_SCORE: 0.6545

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1840V	TCGA-AP-A1DO	UCEC	TCGA	DRAPLPPVP	DEG_APCC_DBOX_1	0.3056
p.A1840V	DO43250	UCEC	ICGC	DRAPLPPVP	DEG_APCC_DBOX_1	0.3056
p.A1840V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DRAPLPPVP	DEG_APCC_DBOX_1	0.3056
p.A1840V	ACH-000995	Leukemia	CCLE	DRAPLPPVP	DEG_APCC_DBOX_1	0.3056
p.A1840V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	DRAPLPPVP	DEG_APCC_DBOX_1	0.3056
p.A1833V	TCGA-FI-A2D5	UCEC	TCGA	DRAPLPPVP	DEG_APCC_DBOX_1	0.5825
p.A1833V	DO50383	ESAD	ICGC	DRAPLPPVP	DEG_APCC_DBOX_1	0.5825
p.A1833V	DO41331	UCEC	ICGC	DRAPLPPVP	DEG_APCC_DBOX_1	0.5825
p.S1847L	TCGA-L5-A4OI	ESCA	TCGA	DRAPLPPVP	DEG_APCC_DBOX_1	0.5556
p.S1847L	TCGA-RU-A8FL	COAD	TCGA	DRAPLPPVP	DEG_APCC_DBOX_1	0.5556
p.S1847L	DO51733	COAD	ICGC	DRAPLPPVP	DEG_APCC_DBOX_1	0.5556
p.P1826T	DO229019	LICA	ICGC	DRAPLPPVP	DEG_APCC_DBOX_1	0.1944
p.S1828L	DO220906	MELA	ICGC	DRAPLPPVP	DEG_APCC_DBOX_1	0.25
p.D1831Y	SIDM00007	Other Solid Cancers	GDSC	DRAPLPPVP	DEG_APCC_DBOX_1	0.6214
p.D1831Y	ACH-001550	Skin Cancer	CCLE	DRAPLPPVP	DEG_APCC_DBOX_1	0.6214
p.D1831Y	MCC13	skin	COSMIC	DRAPLPPVP	DEG_APCC_DBOX_1	0.6214
p.P1839S	SIDM00126	Melanoma	GDSC	DRAPLPPVP	DEG_APCC_DBOX_1	0.5641
p.P1839S	ACH-002147	Skin Cancer	CCLE	DRAPLPPVP	DEG_APCC_DBOX_1	0.5641
p.P1839S	K2	skin	COSMIC	DRAPLPPVP	DEG_APCC_DBOX_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_APCC_DBOX_1	1831:1839	DRAPLPPVP	APC,CDC20,FZR1	0.9799	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons