DegronMD

Uniprot ID: Q5JRA6

Source protein: Transport and Golgi organization protein 1 homolog

Source gene: MIA3

Class: DEG_APCC_DBOX_1

Location: 762:770

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7701

ASA_SCORE: 86.1

COIL: 0.6927

CONS_SCORE: 0.3799

DSS_SCORE: 0.6079

HELIX: 0.1296

FCONS_SCORE: 1.001

RIG_SCORE: 0.7114

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E765K	639-V	urinary_tract	COSMIC	DRAVLGTIH	DEG_APCC_DBOX_1	0.7022
p.D772Y	TCGA-91-6836	LUAD	TCGA	DRAVLGTIH	DEG_APCC_DBOX_1	0.2778
p.D772Y	DO23854	LUAD	ICGC	DRAVLGTIH	DEG_APCC_DBOX_1	0.2778
p.P773L	TCGA-QB-AA9O	SKCM	TCGA	DRAVLGTIH	DEG_APCC_DBOX_1	0.25
p.P773L	DO51267	SKCM	ICGC	DRAVLGTIH	DEG_APCC_DBOX_1	0.25
p.E777K	TCGA-UY-A78K	BLCA	TCGA	DRAVLGTIH	DEG_APCC_DBOX_1	0.1389
p.E777K	DO219031	BLCA	ICGC	DRAVLGTIH	DEG_APCC_DBOX_1	0.1389
p.D755Y	DO222762	COCA	ICGC	DRAVLGTIH	DEG_APCC_DBOX_1	0.1389
p.F754I	SIDM00884	Breast Carcinoma	GDSC	DRAVLGTIH	DEG_APCC_DBOX_1	0.1111
p.F754I	SIDM00337	Melanoma	GDSC	DRAVLGTIH	DEG_APCC_DBOX_1	0.1111
p.F754I	SIDM00883	Non-Cancerous	GDSC	DRAVLGTIH	DEG_APCC_DBOX_1	0.1111
p.S778R	ACH-000034	Primary	CCLE	DRAVLGTIH	DEG_APCC_DBOX_1	0.1111
p.R752M	TCGA-D8-A1XK	BRCA	TCGA	DRAVLGTIH	DEG_APCC_DBOX_1	0.0556
p.R752M	DO4749	BRCA	ICGC	DRAVLGTIH	DEG_APCC_DBOX_1	0.0556

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JRA6	Transport and Golgi organization protein 1 homolog	DEG_APCC_DBOX_1	762:770	DRAVLGTIH	APC,CDC20,FZR1	0.7701	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons