DegronMD - Q5JRA6(MIA3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D772Y	TCGA-91-6836	LUAD	TCGA	DRAVLGTIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.2778
p.D772Y	DO23854	LUAD	ICGC	DRAVLGTIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.2778
p.V347I	TCGA-B5-A3FC	UCEC	TCGA	MKTPAKS	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2778
p.V347I	DO41871	UCEC	ICGC	MKTPAKS	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2778
p.V347I	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	MKTPAKS	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2778
p.V347I	SIDM01318	Hepatocellular Carcinoma	GDSC	MKTPAKS	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2778
p.R752M	TCGA-D8-A1XK	BRCA	TCGA	DRAVLGTIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.0556
p.R752M	DO4749	BRCA	ICGC	DRAVLGTIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.0556
p.K340E	TCGA-DB-A64X	LGG	TCGA	MKTPAKS	DEG_SCF_FBW7_1	339:345	Mutation altering degron motif	0.591
p.K340E	DO44570	LGG	ICGC	MKTPAKS	DEG_SCF_FBW7_1	339:345	Mutation altering degron motif	0.591
p.Y350C	TCGA-DD-AADQ	LIHC	TCGA	MKTPAKS	DEG_SCF_FBW7_1	339:345	Mutation blocking phosphorylation signal	0.6389
p.Y350C	DO52244	LIHC	ICGC	MKTPAKS	DEG_SCF_FBW7_1	339:345	Mutation blocking phosphorylation signal	0.6389
p.P773L	TCGA-QB-AA9O	SKCM	TCGA	DRAVLGTIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.25
p.P773L	DO51267	SKCM	ICGC	DRAVLGTIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.25
p.E777K	TCGA-UY-A78K	BLCA	TCGA	DRAVLGTIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.1389
p.E777K	DO219031	BLCA	ICGC	DRAVLGTIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.1389
p.D755Y	DO222762	COCA	ICGC	DRAVLGTIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.1389
p.F754I	SIDM00884	Breast Carcinoma	GDSC	DRAVLGTIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.1111
p.F754I	SIDM00337	Melanoma	GDSC	DRAVLGTIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.1111
p.F754I	SIDM00883	Non-Cancerous	GDSC	DRAVLGTIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.1111
p.S778R	ACH-000034	Primary	CCLE	DRAVLGTIH	DEG_APCC_DBOX_1	762:770	Mutation rewiring degron network	0.1111
p.D335Y	ACH-000591	Brain Cancer	CCLE	MKTPAKS	DEG_SCF_FBW7_1	339:345	Mutation rewiring degron network	0.2222
p.E765K	639-V	urinary tract	COSMIC	DRAVLGTIH	DEG_APCC_DBOX_1	762:770	Mutation altering degron motif	0.7022

Kaplan plot for MIA3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MIA3

UniProt ID: Q5JRA6

Entrez ID: 375056

Protein name: Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MIA3 in