DegronMD

Uniprot ID: Q5JRA6

Source protein: Transport and Golgi organization protein 1 homolog

Source gene: MIA3

Class: DEG_SCF_FBW7_1

Location: 339:345

E3 ligase: FBXW7

DEGRON score: 0.8701

ASA_SCORE: 97.5143

COIL: 0.8843

CONS_SCORE: 0.3502

DSS_SCORE: 0.6201

HELIX: 0.0449

FCONS_SCORE: 0.8189

RIG_SCORE: 0.6536

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V347I	TCGA-B5-A3FC	UCEC	TCGA	MKTPAKS	DEG_SCF_FBW7_1	0.2778
p.V347I	DO41871	UCEC	ICGC	MKTPAKS	DEG_SCF_FBW7_1	0.2778
p.V347I	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	MKTPAKS	DEG_SCF_FBW7_1	0.2778
p.V347I	SIDM01318	Hepatocellular Carcinoma	GDSC	MKTPAKS	DEG_SCF_FBW7_1	0.2778
p.K340E	TCGA-DB-A64X	LGG	TCGA	MKTPAKS	DEG_SCF_FBW7_1	0.591
p.K340E	DO44570	LGG	ICGC	MKTPAKS	DEG_SCF_FBW7_1	0.591
p.Y350C	TCGA-DD-AADQ	LIHC	TCGA	MKTPAKS	DEG_SCF_FBW7_1	0.6389
p.Y350C	DO52244	LIHC	ICGC	MKTPAKS	DEG_SCF_FBW7_1	0.6389
p.D335Y	ACH-000591	Brain Cancer	CCLE	MKTPAKS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JRA6	Transport and Golgi organization protein 1 homolog	DEG_SCF_FBW7_1	339:345	MKTPAKS	FBXW7	0.8701	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons