DegronMD

Uniprot ID: Q9NPA2

Source protein: Matrix metalloproteinase-25

Source gene: MMP25

Class: DEG_APCC_DBOX_1

Location: 271:279

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7605

ASA_SCORE: 43.7111

COIL: 0.1483

CONS_SCORE: 0.6348

DSS_SCORE: 0.751

HELIX: 0.8449

FCONS_SCORE: 1.5901

RIG_SCORE: 0.7038

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A282T	TCGA-AA-3715	COAD	TCGA	DRDGLQQLY	DEG_APCC_DBOX_1	0.25
p.A282T	DO8018	COAD	ICGC	DRDGLQQLY	DEG_APCC_DBOX_1	0.25
p.G274D	TCGA-AJ-A3EK	UCEC	TCGA	DRDGLQQLY	DEG_APCC_DBOX_1	0.6087
p.G274D	DO220913	MELA	ICGC	DRDGLQQLY	DEG_APCC_DBOX_1	0.6087
p.G274D	DO41584	UCEC	ICGC	DRDGLQQLY	DEG_APCC_DBOX_1	0.6087
p.D273N	TCGA-DA-A3F3	SKCM	TCGA	DRDGLQQLY	DEG_APCC_DBOX_1	0.5821
p.D273N	DO37607	SKCM	ICGC	DRDGLQQLY	DEG_APCC_DBOX_1	0.5821
p.D273N	SIDM00927	Small Cell Lung Carcinoma	GDSC	DRDGLQQLY	DEG_APCC_DBOX_1	0.5821
p.D273N	ACH-000871	Lung Cancer	CCLE	DRDGLQQLY	DEG_APCC_DBOX_1	0.5821
p.D273N	NCI-H510A	lung	COSMIC	DRDGLQQLY	DEG_APCC_DBOX_1	0.5821
p.D271E	TCGA-N8-A4PO	UCS	TCGA	DRDGLQQLY	DEG_APCC_DBOX_1	0.5647
p.K289N	DO229038	LICA	ICGC	DRDGLQQLY	DEG_APCC_DBOX_1	0.1667
p.L267P	SIDM00393	Gastric Carcinoma	GDSC	DRDGLQQLY	DEG_APCC_DBOX_1	0.2222
p.L267P	ACH-001653	Gastric Cancer	CCLE	DRDGLQQLY	DEG_APCC_DBOX_1	0.2222
p.L267P	SK-GT-2	stomach	COSMIC	DRDGLQQLY	DEG_APCC_DBOX_1	0.2222
p.R272C	SIDM01051	Ovarian Carcinoma	GDSC	DRDGLQQLY	DEG_APCC_DBOX_1	0.8301
p.R272C	ACH-000936	Ovarian Cancer	CCLE	DRDGLQQLY	DEG_APCC_DBOX_1	0.8301
p.R272C	EFO-27	ovary	COSMIC	DRDGLQQLY	DEG_APCC_DBOX_1	0.8301
p.P286A	ACH-001318	Liver Cancer	CCLE	DRDGLQQLY	DEG_APCC_DBOX_1	0.1389
p.Y265H	ACH-001389	Breast Cancer	CCLE	DRDGLQQLY	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPA2	Matrix metalloproteinase-25	DEG_APCC_DBOX_1	271:279	DRDGLQQLY	APC,CDC20,FZR1	0.7605	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons