DegronMD - Q9NPA2(MMP25)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A282T	TCGA-AA-3715	COAD	TCGA	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.25
p.A282T	DO8018	COAD	ICGC	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.25
p.R105C	TCGA-AA-A022	COAD	TCGA	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.R105C	DO10647	COAD	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.G274D	TCGA-AJ-A3EK	UCEC	TCGA	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6087
p.G274D	DO220913	MELA	ICGC	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6087
p.G274D	DO41584	UCEC	ICGC	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.6087
p.R106C	TCGA-D1-A1O7	UCEC	TCGA	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.R106C	TCGA-UY-A78L	BLCA	TCGA	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.R106C	DO219032	BLCA	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.R106C	DO41139	UCEC	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.D273N	TCGA-DA-A3F3	SKCM	TCGA	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.5821
p.D273N	DO37607	SKCM	ICGC	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.5821
p.D273N	SIDM00927	Small Cell Lung Carcinoma	GDSC	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.5821
p.D273N	ACH-000871	Lung Cancer	CCLE	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.5821
p.D273N	NCI-H510A	lung	COSMIC	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.5821
p.D78N	TCGA-DU-6392	LGG	TCGA	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.D78N	DO22237	LGG	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.D271E	TCGA-N8-A4PO	UCS	TCGA	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.5647
p.V98E	DO227904	COCA	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2778
p.K87R	DO233930	GACA	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.3056
p.R105H	DO44520	KIRP	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.R105L	DO229018	LICA	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.D94Y	DO229027	LICA	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6214
p.K289N	DO229038	LICA	ICGC	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation substituting flanking lysine	0.1667
p.R104Q	SIDM00216	Colorectal Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.R104Q	SIDM01078	Small Cell Lung Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.R104Q	SIDM00284	Melanoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.R104Q	SIDM01322	Oral Cavity Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.T84I	SIDM00993	Plasma Cell Myeloma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SIDM00496	Thyroid Gland Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SIDM00553	Acute Myeloid Leukemia	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SIDM00057	Neuroblastoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SIDM00552	Rhabdomyosarcoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SIDM00492	Glioblastoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SIDM00242	Osteosarcoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SIDM00567	Other Solid Cancers	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SIDM00381	Cervical Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SIDM01033	Bladder Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SIDM01446	Glioblastoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SIDM01450	Gastric Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SIDM01587	Bladder Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SIDM01391	Neuroblastoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	KYSE-510	oesophagus	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	AM-38	central nervous system	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	SKG-IIIa	cervix	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	NOS-1	bone	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	KY821	haematopoietic and lymphoid tissue	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	HTC-C3	thyroid	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	KU-19-19	urinary tract	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	LU-65	lung	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	KYM-1	soft tissue	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.T84I	ONS-76	central nervous system	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.L267P	SIDM00393	Gastric Carcinoma	GDSC	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2222
p.L267P	ACH-001653	Gastric Cancer	CCLE	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2222
p.L267P	SK-GT-2	stomach	COSMIC	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.2222
p.R86H	SIDM00523	Small Cell Lung Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2778
p.R86H	SIDM00836	Colorectal Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2778
p.A99V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.25
p.R272C	SIDM01051	Ovarian Carcinoma	GDSC	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8301
p.R272C	ACH-000936	Ovarian Cancer	CCLE	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8301
p.R272C	EFO-27	ovary	COSMIC	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation altering degron motif	0.8301
p.R89H	SIDM01443	Gastric Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.8244
p.R89H	ACH-000344	Gastric Cancer	CCLE	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.8244
p.P286A	ACH-001318	Liver Cancer	CCLE	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.1389
p.Y265H	ACH-001389	Breast Cancer	CCLE	DRDGLQQLY	DEG_APCC_DBOX_1	271:279	Mutation rewiring degron network	0.1667
p.D93N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6932
p.A101T	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MMP25

UniProt ID: Q9NPA2

Entrez ID: 64386

Protein name: Matrix metalloproteinase-25 (MMP-25) (EC 3.4.24.-) (Leukolysin) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (MTMMP6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (MT6MMP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MMP25 in