DegronMD

Uniprot ID: Q9NPA2

Source protein: Matrix metalloproteinase-25

Source gene: MMP25

Class: DEG_APCC_DBOX_1

Location: 88:96

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9955

ASA_SCORE: 56.1667

COIL: 0.764

CONS_SCORE: 0.5334

DSS_SCORE: 0.3266

HELIX: 0.0893

FCONS_SCORE: 1.3044

RIG_SCORE: 0.8072

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R105C	TCGA-AA-A022	COAD	TCGA	PRCSLPDVL	DEG_APCC_DBOX_1	0.0833
p.R105C	DO10647	COAD	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	0.0833
p.R106C	TCGA-D1-A1O7	UCEC	TCGA	PRCSLPDVL	DEG_APCC_DBOX_1	0.0556
p.R106C	TCGA-UY-A78L	BLCA	TCGA	PRCSLPDVL	DEG_APCC_DBOX_1	0.0556
p.R106C	DO219032	BLCA	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	0.0556
p.R106C	DO41139	UCEC	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	0.0556
p.D78N	TCGA-DU-6392	LGG	TCGA	PRCSLPDVL	DEG_APCC_DBOX_1	0.0556
p.D78N	DO22237	LGG	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	0.0556
p.V98E	DO227904	COCA	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2778
p.K87R	DO233930	GACA	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	0.3056
p.R105H	DO44520	KIRP	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	0.0833
p.R105L	DO229018	LICA	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	0.0833
p.D94Y	DO229027	LICA	ICGC	PRCSLPDVL	DEG_APCC_DBOX_1	0.6214
p.R104Q	SIDM00216	Colorectal Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.1111
p.R104Q	SIDM01078	Small Cell Lung Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.1111
p.R104Q	SIDM00284	Melanoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.1111
p.R104Q	SIDM01322	Oral Cavity Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.1111
p.T84I	SIDM00993	Plasma Cell Myeloma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SIDM00496	Thyroid Gland Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SIDM00553	Acute Myeloid Leukemia	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SIDM00057	Neuroblastoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SIDM00552	Rhabdomyosarcoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SIDM00492	Glioblastoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SIDM00242	Osteosarcoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SIDM00567	Other Solid Cancers	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SIDM00381	Cervical Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SIDM01033	Bladder Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SIDM01446	Glioblastoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SIDM01450	Gastric Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SIDM01587	Bladder Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SIDM01391	Neuroblastoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	KYSE-510	oesophagus	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	AM-38	central_nervous_system	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	SKG-IIIa	cervix	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	NOS-1	bone	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	KY821	haematopoietic_and_lymphoid_tissue	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	HTC-C3	thyroid	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	KU-19-19	urinary_tract	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	LU-65	lung	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	KYM-1	soft_tissue	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.T84I	ONS-76	central_nervous_system	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2222
p.R86H	SIDM00523	Small Cell Lung Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2778
p.R86H	SIDM00836	Colorectal Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.2778
p.A99V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.25
p.R89H	SIDM01443	Gastric Carcinoma	GDSC	PRCSLPDVL	DEG_APCC_DBOX_1	0.8244
p.R89H	ACH-000344	Gastric Cancer	CCLE	PRCSLPDVL	DEG_APCC_DBOX_1	0.8244
p.D93N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	0.6932
p.A101T	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PRCSLPDVL	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRCSLPDVL

Degron related mutations and impact score

Drug responses associated with MMP25 mutations

All proteins holding degron of PRCSLPDVL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPA2	Matrix metalloproteinase-25	DEG_APCC_DBOX_1	88:96	PRCSLPDVL	APC,CDC20,FZR1	0.9955	More...