DegronMD

Uniprot ID: Q86SU0

Source protein: Immunoglobulin-like domain-containing receptor 1

Source gene: ILDR1

Class: DEG_APCC_DBOX_1

Location: 417:425

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9963

ASA_SCORE: 79.8778

COIL: 0.8322

CONS_SCORE: 0.4166

DSS_SCORE: 0.4806

HELIX: 0.1487

FCONS_SCORE: 1.1057

RIG_SCORE: 0.624

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R433W	TCGA-BR-8081	STAD	TCGA	DRDSLSDVP	DEG_APCC_DBOX_1	0.1111
p.R433W	SIDM01265	Plasma Cell Myeloma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.1111
p.R418M	TCGA-D3-A3CB	SKCM	TCGA	DRDSLSDVP	DEG_APCC_DBOX_1	0.8632
p.P412L	TCGA-EE-A3AH	SKCM	TCGA	DRDSLSDVP	DEG_APCC_DBOX_1	0.1944
p.D423N	TCGA-GN-A4U4	SKCM	TCGA	DRDSLSDVP	DEG_APCC_DBOX_1	0.5821
p.D423N	TCGA-Z2-A8RT	SKCM	TCGA	DRDSLSDVP	DEG_APCC_DBOX_1	0.5821
p.P434L	TCGA-W3-A824	SKCM	TCGA	DRDSLSDVP	DEG_APCC_DBOX_1	0.0833
p.P434L	SIDM00164	Biliary Tract Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.0833
p.R407H	DO10068	COAD	ICGC	DRDSLSDVP	DEG_APCC_DBOX_1	0.0556
p.E422Q	DO228835	LICA	ICGC	DRDSLSDVP	DEG_APCC_DBOX_1	0.6744
p.P415L	DO220902	MELA	ICGC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2778
p.R408K	DO37454	SKCM	ICGC	DRDSLSDVP	DEG_APCC_DBOX_1	0.0833
p.R421Q	DO48665	SKCM	ICGC	DRDSLSDVP	DEG_APCC_DBOX_1	0.7329
p.R421Q	DO219787	UCEC	ICGC	DRDSLSDVP	DEG_APCC_DBOX_1	0.7329
p.S435R	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.0556
p.I413T	SIDM01090	Colorectal Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM00454	Rhabdomyosarcoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM00656	Burkitt's Lymphoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM00087	Plasma Cell Myeloma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM00447	B-Lymphoblastic Leukemia	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM01112	Osteosarcoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM00650	Small Cell Lung Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM00694	Other Solid Cancers	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM00879	Breast Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM00971	Breast Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM00493	Other Solid Cancers	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM00875	Breast Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM00844	Burkitt's Lymphoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM01133	Other Solid Cancers	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM01681	Non-Cancerous	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM01318	Hepatocellular Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM00641	Burkitt's Lymphoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.I413T	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.2222
p.R433Q	SIDM00969	Ovarian Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.1111
p.R433Q	SIDM00654	Small Cell Lung Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.1111
p.R433Q	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.1111
p.R433Q	SIDM00793	Burkitt's Lymphoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.1111
p.R433Q	SIDM00760	Small Cell Lung Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.1111
p.R433Q	SIDM00785	Acute Myeloid Leukemia	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.1111
p.R433Q	SIDM01318	Hepatocellular Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.1111
p.R433Q	SIDM01664	Prostate Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.1111
p.R433Q	SIDM01525	Acute Myeloid Leukemia	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.1111
p.D417Y	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	DRDSLSDVP	DEG_APCC_DBOX_1	0.6214
p.D417Y	ACH-000596	Lung Cancer	CCLE	DRDSLSDVP	DEG_APCC_DBOX_1	0.6214
p.D417Y	LCLC-97TM1	lung	COSMIC	DRDSLSDVP	DEG_APCC_DBOX_1	0.6214
p.R418S	ACH-000215	Brain Cancer	CCLE	DRDSLSDVP	DEG_APCC_DBOX_1	0.7427
p.G409R	NCI-H748	lung	COSMIC	DRDSLSDVP	DEG_APCC_DBOX_1	0.1111
p.R418Q	SUIT-2	pancreas	COSMIC	DRDSLSDVP	DEG_APCC_DBOX_1	0.7329
p.R418Q	SNU-398	liver	COSMIC	DRDSLSDVP	DEG_APCC_DBOX_1	0.7329
p.R418Q	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	DRDSLSDVP	DEG_APCC_DBOX_1	0.7329
p.R418Q	PC-14	lung	COSMIC	DRDSLSDVP	DEG_APCC_DBOX_1	0.7329
p.K419R	NCI-H720	lung	COSMIC	DRDSLSDVP	DEG_APCC_DBOX_1	0.7237
p.P420L	Ca-Ski	cervix	COSMIC	DRDSLSDVP	DEG_APCC_DBOX_1	0.7582
p.E417K	NCI-H187	lung	COSMIC	DRDSLSDVP	DEG_APCC_DBOX_1	0.7022
p.E417K	RKN	ovary	COSMIC	DRDSLSDVP	DEG_APCC_DBOX_1	0.7022
p.R407C	SU-DHL-5	haematopoietic_and_lymphoid_tissue	COSMIC	DRDSLSDVP	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRDSLSDVP

Degron related mutations and impact score

Drug responses associated with ILDR1 mutations

All proteins holding degron of DRDSLSDVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86SU0	Immunoglobulin-like domain-containing receptor 1	DEG_APCC_DBOX_1	417:425	DRDSLSDVP	APC,CDC20,FZR1	0.9963	More...