DegronMD

Uniprot ID: Q68DN1

Source protein: Uncharacterized protein C2orf16

Source gene: C2orf16

Class: DEG_APCC_DBOX_1

Location: 1039:1047

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9726

ASA_SCORE: 91.5333

COIL: 0.7153

CONS_SCORE: 0.8772

DSS_SCORE: 0.5334

HELIX: 0.1081

FCONS_SCORE: 1.0018

RIG_SCORE: 0.7636

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1054R	TCGA-56-6546	LUSC	TCGA	DREDLVPME	DEG_APCC_DBOX_1	0.5833
p.S1054R	DO26542	LUSC	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.5833
p.Q1053H	TCGA-63-5131	LUSC	TCGA	DREDLVPME	DEG_APCC_DBOX_1	0.1667
p.Q1053H	DO229019	LICA	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.1667
p.Q1053H	DO26898	LUSC	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.1667
p.L1043I	TCGA-AA-3984	COAD	TCGA	DREDLVPME	DEG_APCC_DBOX_1	0.7174
p.L1043I	DO9002	COAD	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.7174
p.D1039N	TCGA-C5-A1BK	CESC	TCGA	DREDLVPME	DEG_APCC_DBOX_1	0.5821
p.D1039N	TCGA-EE-A2MD	SKCM	TCGA	DREDLVPME	DEG_APCC_DBOX_1	0.5821
p.D1039N	DO6266	CESC	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.5821
p.D1039N	DO222434	MELA	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.5821
p.D1039N	DO37851	SKCM	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.5821
p.D1055N	TCGA-EE-A2MS	SKCM	TCGA	DREDLVPME	DEG_APCC_DBOX_1	0.1111
p.D1055N	DO37567	SKCM	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.1111
p.M1046I	TCGA-ER-A19F	SKCM	TCGA	DREDLVPME	DEG_APCC_DBOX_1	0.6507
p.M1046I	DO229035	LICA	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.6507
p.M1046I	DO37679	SKCM	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.6507
p.E1047K	TCGA-ER-A19F	SKCM	TCGA	DREDLVPME	DEG_APCC_DBOX_1	0.591
p.E1047K	DO37679	SKCM	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.591
p.S1033F	TCGA-VP-A87C	PRAD	TCGA	DREDLVPME	DEG_APCC_DBOX_1	0.1667
p.S1033F	DO51384	PRAD	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.1667
p.K1029N	DO229026	LICA	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.1667
p.L1034F	DO52657	MALY	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.1944
p.L1034F	SIDM01588	Endometrial Carcinoma	GDSC	DREDLVPME	DEG_APCC_DBOX_1	0.1944
p.L1034F	ACH-000993	Endometrial/Uterine Cancer	CCLE	DREDLVPME	DEG_APCC_DBOX_1	0.1944
p.S1056F	DO222743	MELA	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.5278
p.R1040T	DO51509	PACA	ICGC	DREDLVPME	DEG_APCC_DBOX_1	0.7876
p.D1051G	SIDM01248	Thyroid Gland Carcinoma	GDSC	DREDLVPME	DEG_APCC_DBOX_1	0.2222
p.D1051G	ACH-001023	Thyroid Cancer	CCLE	DREDLVPME	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DREDLVPME

Degron related mutations and impact score

Drug responses associated with C2orf16 mutations

All proteins holding degron of DREDLVPME

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DN1	Uncharacterized protein C2orf16	DEG_APCC_DBOX_1	1039:1047	DREDLVPME	APC,CDC20,FZR1	0.9726	More...