DegronMD - Q68DN1(C2orf16)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I285K	TCGA-33-AASL	LUSC	TCGA	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.1111
p.I285K	DO219133	LUSC	ICGC	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.1111
p.S308C	TCGA-34-2596	LUSC	TCGA	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.0556
p.S308C	DO26508	LUSC	ICGC	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.0556
p.L17F	TCGA-4Z-AA86	BLCA	TCGA	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation rewiring degron network	0.1667
p.L17F	DO218989	BLCA	ICGC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation rewiring degron network	0.1667
p.Q22K	TCGA-55-A490	LUAD	TCGA	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation rewiring degron network	0.3056
p.Q22K	DO24596	LUAD	ICGC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation rewiring degron network	0.3056
p.S1054R	TCGA-56-6546	LUSC	TCGA	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation blocking phosphorylation signal	0.5833
p.S1054R	DO26542	LUSC	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation blocking phosphorylation signal	0.5833
p.Q1053H	TCGA-63-5131	LUSC	TCGA	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1667
p.Q1053H	DO229019	LICA	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1667
p.Q1053H	DO26898	LUSC	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1667
p.K177Q	TCGA-66-2787	LUSC	TCGA	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.2778
p.K177Q	DO26647	LUSC	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.2778
p.V24E	TCGA-85-7950	LUSC	TCGA	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation altering degron motif	0.6582
p.V24E	DO26878	LUSC	ICGC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation altering degron motif	0.6582
p.G292V	TCGA-98-8021	LUSC	TCGA	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.3056
p.G292V	DO27468	LUSC	ICGC	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.3056
p.A287S	TCGA-A5-A2K5	UCEC	TCGA	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.1667
p.A287S	DO41379	UCEC	ICGC	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.1667
p.L1043I	TCGA-AA-3984	COAD	TCGA	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.7174
p.L1043I	DO9002	COAD	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.7174
p.K219Q	TCGA-AG-A002	READ	TCGA	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2778
p.N13H	TCGA-AP-A056	UCEC	TCGA	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation rewiring degron network	0.0556
p.N13H	TCGA-AZ-4315	COAD	TCGA	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation rewiring degron network	0.0556
p.N13H	DO8842	COAD	ICGC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation rewiring degron network	0.0556
p.N13H	DO43971	UCEC	ICGC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation rewiring degron network	0.0556
p.L1428S	TCGA-AP-A0LG	UCEC	TCGA	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation rewiring degron network	0.1111
p.L1428S	DO41823	UCEC	ICGC	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation rewiring degron network	0.1111
p.D1408Y	TCGA-AX-A05Z	UCEC	TCGA	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation rewiring degron network	0.1389
p.D1408Y	DO40884	UCEC	ICGC	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation rewiring degron network	0.1389
p.E16A	TCGA-B5-A1MR	UCEC	TCGA	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation rewiring degron network	0.1389
p.E16A	DO41758	UCEC	ICGC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation rewiring degron network	0.1389
p.S178Y	TCGA-BS-A0UF	UCEC	TCGA	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation blocking phosphorylation signal	0.75
p.S178Y	DO222762	COCA	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation blocking phosphorylation signal	0.75
p.S178Y	DO41488	UCEC	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation blocking phosphorylation signal	0.75
p.D1408G	TCGA-BT-A3PK	BLCA	TCGA	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation rewiring degron network	0.1389
p.D1408G	DO44051	BLCA	ICGC	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation rewiring degron network	0.1389
p.D1039N	TCGA-C5-A1BK	CESC	TCGA	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.5821
p.D1039N	TCGA-EE-A2MD	SKCM	TCGA	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.5821
p.D1039N	DO6266	CESC	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.5821
p.D1039N	DO222434	MELA	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.5821
p.D1039N	DO37851	SKCM	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.5821
p.L1415I	TCGA-CA-6717	COAD	TCGA	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation altering degron motif	0.6063
p.L1415I	DO8264	COAD	ICGC	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation altering degron motif	0.6063
p.P295S	TCGA-D1-A103	UCEC	TCGA	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation altering degron motif	0.6752
p.P295S	DO42312	UCEC	ICGC	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation altering degron motif	0.6752
p.M27I	TCGA-D3-A8GI	SKCM	TCGA	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation altering degron motif	0.6507
p.M27I	DO50284	SKCM	ICGC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation altering degron motif	0.6507
p.M27I	SIDM00857	Melanoma	GDSC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation altering degron motif	0.6507
p.M27I	ACH-000572	Skin Cancer	CCLE	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation altering degron motif	0.6507
p.T298A	TCGA-D9-A6EC	SKCM	TCGA	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation altering degron motif	0.7139
p.T298A	DO50291	SKCM	ICGC	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation altering degron motif	0.7139
p.T298A	SIDM01045	Endometrial Carcinoma	GDSC	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation altering degron motif	0.7139
p.T298A	ACH-000978	Endometrial/Uterine Cancer	CCLE	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation altering degron motif	0.7139
p.F290L	TCGA-DK-A6AW	BLCA	TCGA	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.25
p.F290L	DO48566	BLCA	ICGC	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.25
p.F290L	DO222762	COCA	ICGC	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.25
p.D173N	TCGA-DU-6392	LGG	TCGA	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1667
p.D173N	DO22237	LGG	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1667
p.G303R	TCGA-EE-A2MN	SKCM	TCGA	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.1944
p.G303R	DO37423	SKCM	ICGC	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.1944
p.G303E	TCGA-EE-A2MN	SKCM	TCGA	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.1944
p.G303E	DO222837	MELA	ICGC	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.1944
p.G303E	DO37423	SKCM	ICGC	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.1944
p.D1055N	TCGA-EE-A2MS	SKCM	TCGA	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1111
p.D1055N	DO37567	SKCM	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1111
p.M1046I	TCGA-ER-A19F	SKCM	TCGA	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.6507
p.M1046I	DO229035	LICA	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.6507
p.M1046I	DO37679	SKCM	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.6507
p.E1047K	TCGA-ER-A19F	SKCM	TCGA	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.591
p.E1047K	DO37679	SKCM	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.591
p.V213I	TCGA-F5-6814	READ	TCGA	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1111
p.V213I	DO36556	READ	ICGC	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1111
p.R284M	TCGA-G4-6320	COAD	TCGA	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.0833
p.R284M	DO8159	COAD	ICGC	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.0833
p.S1033F	TCGA-VP-A87C	PRAD	TCGA	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1667
p.S1033F	DO51384	PRAD	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1667
p.E236K	TCGA-W3-AA1V	SKCM	TCGA	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1111
p.E236K	DO51276	SKCM	ICGC	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1111
p.P183L	TCGA-WE-AAA0	SKCM	TCGA	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.7582
p.P183L	DO51294	SKCM	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.7582
p.Y14F	TCGA-YL-A9WK	PRAD	TCGA	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation rewiring degron network	0.0833
p.Y14F	DO51443	PRAD	ICGC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation rewiring degron network	0.0833
p.S218L	DO225140	BRCA	ICGC	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.25
p.K25N	DO222798	COCA	ICGC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation altering degron motif	0.5806
p.G187D	DO222884	COCA	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.3056
p.E176D	DO223029	ESCA	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.25
p.W1429C	DO228974	LICA	ICGC	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation rewiring degron network	0.0833
p.W1429C	ACH-001685	Lymphoma	CCLE	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation rewiring degron network	0.0833
p.K1029N	DO229026	LICA	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation substituting flanking lysine	0.1667
p.E32D	DO229008	LICA	ICGC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation altering degron motif	0.5647
p.L1034F	DO52657	MALY	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1944
p.L1034F	SIDM01588	Endometrial Carcinoma	GDSC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1944
p.L1034F	ACH-000993	Endometrial/Uterine Cancer	CCLE	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.1944
p.E191K	DO222572	MELA	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1944
p.G194E	DO222653	MELA	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1111
p.G194E	ACH-001970	Metastasis	CCLE	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1111
p.S1056F	DO222743	MELA	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation blocking phosphorylation signal	0.5278
p.D1413H	DO27879	ORCA	ICGC	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation rewiring degron network	0.2778
p.R1040T	DO51509	PACA	ICGC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation altering degron motif	0.7876
p.M212L	DO46909	RECA	ICGC	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.0833
p.M212K	SIDM00215	Colorectal Carcinoma	GDSC	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.0833
p.M212K	ACH-000708	Colon/Colorectal Cancer	CCLE	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.0833
p.L219V	SIDM00304	Ovarian Carcinoma	GDSC	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2778
p.D1051G	SIDM01248	Thyroid Gland Carcinoma	GDSC	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.2222
p.D1051G	ACH-001023	Thyroid Cancer	CCLE	DREDLVPME	DEG_APCC_DBOX_1	1039:1047	Mutation rewiring degron network	0.2222
p.R1410K	SIDM00795	Melanoma	GDSC	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation rewiring degron network	0.1944
p.R1410K	ACH-000219	Skin Cancer	CCLE	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation rewiring degron network	0.1944
p.R1410K	ACH-002001	Skin Cancer	CCLE	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation rewiring degron network	0.1944
p.R1410K	ACH-002002	Skin Cancer	CCLE	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation rewiring degron network	0.1944
p.R1410K	ACH-002003	Skin Cancer	CCLE	LTPAGS	DEG_SCF_FBW7_1	1415:1420	Mutation rewiring degron network	0.1944
p.S192C	SIDM01154	T-Lymphoblastic Leukemia	GDSC	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1667
p.S192C	ACH-000953	Leukemia	CCLE	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1667
p.I25T	SIDM00350	Head and Neck Carcinoma	GDSC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation altering degron motif	0.7078
p.I25T	SIDM01180	Hepatocellular Carcinoma	GDSC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation altering degron motif	0.7078
p.I25T	SIDM00365	Small Cell Lung Carcinoma	GDSC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation altering degron motif	0.7078
p.I25T	SIDM00612	Glioma	GDSC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation altering degron motif	0.7078
p.I25T	SIDM00217	Colorectal Carcinoma	GDSC	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation altering degron motif	0.7078
p.S172F	SIDM01106	Melanoma	GDSC	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1389
p.I232N	SIDM00619	Thyroid Gland Carcinoma	GDSC	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2222
p.G216S	SIDM00556	Neuroblastoma	GDSC	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1944
p.G216S	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1944
p.E308Q	SIDM00767	Small Cell Lung Carcinoma	GDSC	MTPKPT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.0556
p.K170E	SIDM00143	Small Cell Lung Carcinoma	GDSC	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation substituting flanking lysine	0.1944
p.K170E	ACH-000803	Lung Cancer	CCLE	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation substituting flanking lysine	0.1944
p.D173Y	SIDM00628	Breast Carcinoma	GDSC	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1667
p.D173Y	ACH-000849	Breast Cancer	CCLE	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1667
p.M235V	SIDM01393	Gastric Carcinoma	GDSC	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1389
p.M235V	ACH-000466	Gastric Cancer	CCLE	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1389
p.L223S	SIDM01611	Endometrial Carcinoma	GDSC	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.6556
p.L223S	ACH-000996	Endometrial/Uterine Cancer	CCLE	LGLTPEKS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.6556
p.G180R	ACH-000296	Colon/Colorectal Cancer	CCLE	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation altering degron motif	0.6457
p.Q15E	ACH-000512	Myeloma	CCLE	DVKSMMLVPEP	DEG_COP1_1	23:33	Mutation rewiring degron network	0.1111
p.I172T	ACH-001957	Bone Cancer	CCLE	VGLTPKLT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C2orf16

UniProt ID: Q68DN1

Entrez ID: 84226

Protein name: Uncharacterized protein C2orf16

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for C2orf16 in