DegronMD

Uniprot ID: Q68DN1

Source protein: Uncharacterized protein C2orf16

Source gene: C2orf16

Class: DEG_COP1_1

Location: 23:33

E3 ligase: COP1

DEGRON score: 0.7431

ASA_SCORE: 90.3091

COIL: 0.6485

CONS_SCORE: 0.5715

DSS_SCORE: 0.4587

HELIX: 0.0208

FCONS_SCORE: 0.8368

RIG_SCORE: 0.7788

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L17F	TCGA-4Z-AA86	BLCA	TCGA	DVKSMMLVPEP	DEG_COP1_1	0.1667
p.L17F	DO218989	BLCA	ICGC	DVKSMMLVPEP	DEG_COP1_1	0.1667
p.Q22K	TCGA-55-A490	LUAD	TCGA	DVKSMMLVPEP	DEG_COP1_1	0.3056
p.Q22K	DO24596	LUAD	ICGC	DVKSMMLVPEP	DEG_COP1_1	0.3056
p.V24E	TCGA-85-7950	LUSC	TCGA	DVKSMMLVPEP	DEG_COP1_1	0.6582
p.V24E	DO26878	LUSC	ICGC	DVKSMMLVPEP	DEG_COP1_1	0.6582
p.N13H	TCGA-AP-A056	UCEC	TCGA	DVKSMMLVPEP	DEG_COP1_1	0.0556
p.N13H	TCGA-AZ-4315	COAD	TCGA	DVKSMMLVPEP	DEG_COP1_1	0.0556
p.N13H	DO8842	COAD	ICGC	DVKSMMLVPEP	DEG_COP1_1	0.0556
p.N13H	DO43971	UCEC	ICGC	DVKSMMLVPEP	DEG_COP1_1	0.0556
p.E16A	TCGA-B5-A1MR	UCEC	TCGA	DVKSMMLVPEP	DEG_COP1_1	0.1389
p.E16A	DO41758	UCEC	ICGC	DVKSMMLVPEP	DEG_COP1_1	0.1389
p.M27I	TCGA-D3-A8GI	SKCM	TCGA	DVKSMMLVPEP	DEG_COP1_1	0.6507
p.M27I	DO50284	SKCM	ICGC	DVKSMMLVPEP	DEG_COP1_1	0.6507
p.M27I	SIDM00857	Melanoma	GDSC	DVKSMMLVPEP	DEG_COP1_1	0.6507
p.M27I	ACH-000572	Skin Cancer	CCLE	DVKSMMLVPEP	DEG_COP1_1	0.6507
p.Y14F	TCGA-YL-A9WK	PRAD	TCGA	DVKSMMLVPEP	DEG_COP1_1	0.0833
p.Y14F	DO51443	PRAD	ICGC	DVKSMMLVPEP	DEG_COP1_1	0.0833
p.K25N	DO222798	COCA	ICGC	DVKSMMLVPEP	DEG_COP1_1	0.5806
p.E32D	DO229008	LICA	ICGC	DVKSMMLVPEP	DEG_COP1_1	0.5647
p.I25T	SIDM00350	Head and Neck Carcinoma	GDSC	DVKSMMLVPEP	DEG_COP1_1	0.7078
p.I25T	SIDM01180	Hepatocellular Carcinoma	GDSC	DVKSMMLVPEP	DEG_COP1_1	0.7078
p.I25T	SIDM00365	Small Cell Lung Carcinoma	GDSC	DVKSMMLVPEP	DEG_COP1_1	0.7078
p.I25T	SIDM00612	Glioma	GDSC	DVKSMMLVPEP	DEG_COP1_1	0.7078
p.I25T	SIDM00217	Colorectal Carcinoma	GDSC	DVKSMMLVPEP	DEG_COP1_1	0.7078
p.Q15E	ACH-000512	Myeloma	CCLE	DVKSMMLVPEP	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DN1	Uncharacterized protein C2orf16	DEG_COP1_1	23:33	DVKSMMLVPEP	COP1	0.7431	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons