DegronMD

Uniprot ID: Q68DN1

Source protein: Uncharacterized protein C2orf16

Source gene: C2orf16

Class: DEG_SCF_FBW7_1

Location: 179:186

E3 ligase: FBXW7

DEGRON score: 0.9203

ASA_SCORE: 83.3375

COIL: 0.8964

CONS_SCORE: 0.6521

DSS_SCORE: 0.383

HELIX: 0.0188

FCONS_SCORE: 0.9924

RIG_SCORE: 0.7587

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P183L	TCGA-WE-AAA0	SKCM	TCGA	VGLTPKLT	DEG_SCF_FBW7_1	0.7582
p.P183L	DO51294	SKCM	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	0.7582
p.S178Y	TCGA-BS-A0UF	UCEC	TCGA	VGLTPKLT	DEG_SCF_FBW7_1	0.75
p.S178Y	DO222762	COCA	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	0.75
p.S178Y	DO41488	UCEC	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	0.75
p.G180R	ACH-000296	Colon/Colorectal Cancer	CCLE	VGLTPKLT	DEG_SCF_FBW7_1	0.6457
p.G187D	DO222884	COCA	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	0.3056
p.K177Q	TCGA-66-2787	LUSC	TCGA	VGLTPKLT	DEG_SCF_FBW7_1	0.2778
p.K177Q	DO26647	LUSC	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	0.2778
p.E176D	DO223029	ESCA	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	0.25
p.E191K	DO222572	MELA	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	0.1944
p.K170E	SIDM00143	Small Cell Lung Carcinoma	GDSC	VGLTPKLT	DEG_SCF_FBW7_1	0.1944
p.K170E	ACH-000803	Lung Cancer	CCLE	VGLTPKLT	DEG_SCF_FBW7_1	0.1944
p.D173N	TCGA-DU-6392	LGG	TCGA	VGLTPKLT	DEG_SCF_FBW7_1	0.1667
p.D173N	DO22237	LGG	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	0.1667
p.S192C	SIDM01154	T-Lymphoblastic Leukemia	GDSC	VGLTPKLT	DEG_SCF_FBW7_1	0.1667
p.S192C	ACH-000953	Leukemia	CCLE	VGLTPKLT	DEG_SCF_FBW7_1	0.1667
p.D173Y	SIDM00628	Breast Carcinoma	GDSC	VGLTPKLT	DEG_SCF_FBW7_1	0.1667
p.D173Y	ACH-000849	Breast Cancer	CCLE	VGLTPKLT	DEG_SCF_FBW7_1	0.1667
p.S172F	SIDM01106	Melanoma	GDSC	VGLTPKLT	DEG_SCF_FBW7_1	0.1389
p.I172T	ACH-001957	Bone Cancer	CCLE	VGLTPKLT	DEG_SCF_FBW7_1	0.1389
p.G194E	DO222653	MELA	ICGC	VGLTPKLT	DEG_SCF_FBW7_1	0.1111
p.G194E	ACH-001970	Metastasis	CCLE	VGLTPKLT	DEG_SCF_FBW7_1	0.1111

Showing 1 to 23 of 23 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DN1	Uncharacterized protein C2orf16	DEG_SCF_FBW7_1	179:186	VGLTPKLT	FBXW7	0.9203	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons