DegronMD

Uniprot ID: Q68DN1

Source protein: Uncharacterized protein C2orf16

Source gene: C2orf16

Class: DEG_SCF_FBW7_1

Location: 293:298

E3 ligase: FBXW7

DEGRON score: 0.843

ASA_SCORE: 95.5

COIL: 0.9138

CONS_SCORE: 0.6916

DSS_SCORE: 0.4892

HELIX: 0.0188

FCONS_SCORE: 1.0321

RIG_SCORE: 0.7018

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I285K	TCGA-33-AASL	LUSC	TCGA	MTPKPT	DEG_SCF_FBW7_1	0.1111
p.I285K	DO219133	LUSC	ICGC	MTPKPT	DEG_SCF_FBW7_1	0.1111
p.S308C	TCGA-34-2596	LUSC	TCGA	MTPKPT	DEG_SCF_FBW7_1	0.0556
p.S308C	DO26508	LUSC	ICGC	MTPKPT	DEG_SCF_FBW7_1	0.0556
p.G292V	TCGA-98-8021	LUSC	TCGA	MTPKPT	DEG_SCF_FBW7_1	0.3056
p.G292V	DO27468	LUSC	ICGC	MTPKPT	DEG_SCF_FBW7_1	0.3056
p.A287S	TCGA-A5-A2K5	UCEC	TCGA	MTPKPT	DEG_SCF_FBW7_1	0.1667
p.A287S	DO41379	UCEC	ICGC	MTPKPT	DEG_SCF_FBW7_1	0.1667
p.P295S	TCGA-D1-A103	UCEC	TCGA	MTPKPT	DEG_SCF_FBW7_1	0.6752
p.P295S	DO42312	UCEC	ICGC	MTPKPT	DEG_SCF_FBW7_1	0.6752
p.T298A	TCGA-D9-A6EC	SKCM	TCGA	MTPKPT	DEG_SCF_FBW7_1	0.7139
p.T298A	DO50291	SKCM	ICGC	MTPKPT	DEG_SCF_FBW7_1	0.7139
p.T298A	SIDM01045	Endometrial Carcinoma	GDSC	MTPKPT	DEG_SCF_FBW7_1	0.7139
p.T298A	ACH-000978	Endometrial/Uterine Cancer	CCLE	MTPKPT	DEG_SCF_FBW7_1	0.7139
p.F290L	TCGA-DK-A6AW	BLCA	TCGA	MTPKPT	DEG_SCF_FBW7_1	0.25
p.F290L	DO48566	BLCA	ICGC	MTPKPT	DEG_SCF_FBW7_1	0.25
p.F290L	DO222762	COCA	ICGC	MTPKPT	DEG_SCF_FBW7_1	0.25
p.G303R	TCGA-EE-A2MN	SKCM	TCGA	MTPKPT	DEG_SCF_FBW7_1	0.1944
p.G303R	DO37423	SKCM	ICGC	MTPKPT	DEG_SCF_FBW7_1	0.1944
p.G303E	TCGA-EE-A2MN	SKCM	TCGA	MTPKPT	DEG_SCF_FBW7_1	0.1944
p.G303E	DO222837	MELA	ICGC	MTPKPT	DEG_SCF_FBW7_1	0.1944
p.G303E	DO37423	SKCM	ICGC	MTPKPT	DEG_SCF_FBW7_1	0.1944
p.R284M	TCGA-G4-6320	COAD	TCGA	MTPKPT	DEG_SCF_FBW7_1	0.0833
p.R284M	DO8159	COAD	ICGC	MTPKPT	DEG_SCF_FBW7_1	0.0833
p.E308Q	SIDM00767	Small Cell Lung Carcinoma	GDSC	MTPKPT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DN1	Uncharacterized protein C2orf16	DEG_SCF_FBW7_1	293:298	MTPKPT	FBXW7	0.843	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons