DegronMD

Uniprot ID: Q68DN1

Source protein: Uncharacterized protein C2orf16

Source gene: C2orf16

Class: DEG_SCF_FBW7_1

Location: 221:228

E3 ligase: FBXW7

DEGRON score: 0.6379

ASA_SCORE: 87.1125

COIL: 0.8003

CONS_SCORE: 0.6916

DSS_SCORE: 0.306

HELIX: 0.0305

FCONS_SCORE: 1.0104

RIG_SCORE: 0.7727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K219Q	TCGA-AG-A002	READ	TCGA	LGLTPEKS	DEG_SCF_FBW7_1	0.2778
p.V213I	TCGA-F5-6814	READ	TCGA	LGLTPEKS	DEG_SCF_FBW7_1	0.1111
p.V213I	DO36556	READ	ICGC	LGLTPEKS	DEG_SCF_FBW7_1	0.1111
p.E236K	TCGA-W3-AA1V	SKCM	TCGA	LGLTPEKS	DEG_SCF_FBW7_1	0.1111
p.E236K	DO51276	SKCM	ICGC	LGLTPEKS	DEG_SCF_FBW7_1	0.1111
p.S218L	DO225140	BRCA	ICGC	LGLTPEKS	DEG_SCF_FBW7_1	0.25
p.M212L	DO46909	RECA	ICGC	LGLTPEKS	DEG_SCF_FBW7_1	0.0833
p.M212K	SIDM00215	Colorectal Carcinoma	GDSC	LGLTPEKS	DEG_SCF_FBW7_1	0.0833
p.M212K	ACH-000708	Colon/Colorectal Cancer	CCLE	LGLTPEKS	DEG_SCF_FBW7_1	0.0833
p.L219V	SIDM00304	Ovarian Carcinoma	GDSC	LGLTPEKS	DEG_SCF_FBW7_1	0.2778
p.I232N	SIDM00619	Thyroid Gland Carcinoma	GDSC	LGLTPEKS	DEG_SCF_FBW7_1	0.2222
p.G216S	SIDM00556	Neuroblastoma	GDSC	LGLTPEKS	DEG_SCF_FBW7_1	0.1944
p.G216S	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	LGLTPEKS	DEG_SCF_FBW7_1	0.1944
p.M235V	SIDM01393	Gastric Carcinoma	GDSC	LGLTPEKS	DEG_SCF_FBW7_1	0.1389
p.M235V	ACH-000466	Gastric Cancer	CCLE	LGLTPEKS	DEG_SCF_FBW7_1	0.1389
p.L223S	SIDM01611	Endometrial Carcinoma	GDSC	LGLTPEKS	DEG_SCF_FBW7_1	0.6556
p.L223S	ACH-000996	Endometrial/Uterine Cancer	CCLE	LGLTPEKS	DEG_SCF_FBW7_1	0.6556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DN1	Uncharacterized protein C2orf16	DEG_SCF_FBW7_1	221:228	LGLTPEKS	FBXW7	0.6379	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons