DegronMD

Uniprot ID: Q68DN1

Source protein: Uncharacterized protein C2orf16

Source gene: C2orf16

Class: DEG_SCF_FBW7_1

Location: 1415:1420

E3 ligase: FBXW7

DEGRON score: 0.9923

ASA_SCORE: 78.75

COIL: 0.9673

CONS_SCORE: 0.6916

DSS_SCORE: 0.4933

HELIX: 0.016

FCONS_SCORE: 1.029

RIG_SCORE: 0.6776

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1428S	TCGA-AP-A0LG	UCEC	TCGA	LTPAGS	DEG_SCF_FBW7_1	0.1111
p.L1428S	DO41823	UCEC	ICGC	LTPAGS	DEG_SCF_FBW7_1	0.1111
p.D1408Y	TCGA-AX-A05Z	UCEC	TCGA	LTPAGS	DEG_SCF_FBW7_1	0.1389
p.D1408Y	DO40884	UCEC	ICGC	LTPAGS	DEG_SCF_FBW7_1	0.1389
p.D1408G	TCGA-BT-A3PK	BLCA	TCGA	LTPAGS	DEG_SCF_FBW7_1	0.1389
p.D1408G	DO44051	BLCA	ICGC	LTPAGS	DEG_SCF_FBW7_1	0.1389
p.L1415I	TCGA-CA-6717	COAD	TCGA	LTPAGS	DEG_SCF_FBW7_1	0.6063
p.L1415I	DO8264	COAD	ICGC	LTPAGS	DEG_SCF_FBW7_1	0.6063
p.W1429C	DO228974	LICA	ICGC	LTPAGS	DEG_SCF_FBW7_1	0.0833
p.W1429C	ACH-001685	Lymphoma	CCLE	LTPAGS	DEG_SCF_FBW7_1	0.0833
p.D1413H	DO27879	ORCA	ICGC	LTPAGS	DEG_SCF_FBW7_1	0.2778
p.R1410K	SIDM00795	Melanoma	GDSC	LTPAGS	DEG_SCF_FBW7_1	0.1944
p.R1410K	ACH-000219	Skin Cancer	CCLE	LTPAGS	DEG_SCF_FBW7_1	0.1944
p.R1410K	ACH-002001	Skin Cancer	CCLE	LTPAGS	DEG_SCF_FBW7_1	0.1944
p.R1410K	ACH-002002	Skin Cancer	CCLE	LTPAGS	DEG_SCF_FBW7_1	0.1944
p.R1410K	ACH-002003	Skin Cancer	CCLE	LTPAGS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DN1	Uncharacterized protein C2orf16	DEG_SCF_FBW7_1	1415:1420	LTPAGS	FBXW7	0.9923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons