DegronMD

Uniprot ID: Q9Y5S2

Source protein: Serine/threonine-protein kinase MRCK beta

Source gene: CDC42BPB

Class: DEG_APCC_DBOX_1

Location: 411:419

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7803

ASA_SCORE: 58.8111

COIL: 0.5614

CONS_SCORE: 0.3794

DSS_SCORE: 0.3298

HELIX: 0.3166

FCONS_SCORE: 0.8358

RIG_SCORE: 0.7603

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E428K	TCGA-BH-A18P	BRCA	TCGA	DRGSLKSIM	DEG_APCC_DBOX_1	0.0833
p.E428K	DO3346	BRCA	ICGC	DRGSLKSIM	DEG_APCC_DBOX_1	0.0833
p.T405M	TCGA-IB-7651	PAAD	TCGA	DRGSLKSIM	DEG_APCC_DBOX_1	0.1667
p.T405M	DO46657	PAAD	ICGC	DRGSLKSIM	DEG_APCC_DBOX_1	0.1667
p.T405M	DO232224	PBCA	ICGC	DRGSLKSIM	DEG_APCC_DBOX_1	0.1667
p.I418T	DO35242	PACA	ICGC	DRGSLKSIM	DEG_APCC_DBOX_1	0.7078
p.D411N	SIDM00272	Breast Carcinoma	GDSC	DRGSLKSIM	DEG_APCC_DBOX_1	0.5821
p.D411N	ACH-000910	Breast Cancer	CCLE	DRGSLKSIM	DEG_APCC_DBOX_1	0.5821
p.D411N	MDA-MB-453	breast	COSMIC	DRGSLKSIM	DEG_APCC_DBOX_1	0.5821
p.E428D	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	DRGSLKSIM	DEG_APCC_DBOX_1	0.0833
p.E428D	ACH-000925	Lung Cancer	CCLE	DRGSLKSIM	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5S2	Serine/threonine-protein kinase MRCK beta	DEG_APCC_DBOX_1	411:419	DRGSLKSIM	APC,CDC20,FZR1	0.7803	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons