DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DRHKYSCPP
Uniprot ID:
Q9H6J7
Source protein:
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1
Source gene:
CSTPP1
Class:
CBL_PTK
Location:
211:219
E3 ligase:
CBL
DEGRON score:
0.582
ASA_SCORE:
67.9444
COIL:
0.7622
CONS_SCORE:
0.4464
DSS_SCORE:
0.0764
HELIX:
0.1434
FCONS_SCORE:
1.1374
RIG_SCORE:
0.8144
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q204K
TCGA-85-6561
LUSC
TCGA
DRHKYSCPP
CBL_PTK
0.1389
p.Q204K
DO26518
LUSC
ICGC
DRHKYSCPP
CBL_PTK
0.1389
p.R212L
TCGA-ER-A19B
SKCM
TCGA
DRHKYSCPP
CBL_PTK
0.7316
p.R212L
DO47491
SKCM
ICGC
DRHKYSCPP
CBL_PTK
0.7316
p.S228N
DO227969
COCA
ICGC
DRHKYSCPP
CBL_PTK
0.5278
p.F202L
DO231086
LUSC
ICGC
DRHKYSCPP
CBL_PTK
0.0833
p.R212W
DO232224
PBCA
ICGC
DRHKYSCPP
CBL_PTK
0.7523
Drug responses associated with CSTPP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DRHKYSCPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H6J7
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1
CBL_PTK
211:219
DRHKYSCPP
CBL
0.582
More...
