DegronMD

Uniprot ID: Q9P2M4

Source protein: TBC1 domain family member 14

Source gene: TBC1D14

Class: DEG_APCC_DBOX_1

Location: 57:65

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9861

ASA_SCORE: 80.1111

COIL: 0.7021

CONS_SCORE: 0.3593

DSS_SCORE: 0.4249

HELIX: 0.2177

FCONS_SCORE: 1.022

RIG_SCORE: 0.7079

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G74W	TCGA-05-4396	LUAD	TCGA	DRHSLQSVD	DEG_APCC_DBOX_1	0.0833
p.G74W	DO23838	LUAD	ICGC	DRHSLQSVD	DEG_APCC_DBOX_1	0.0833
p.E72K	TCGA-IB-7651	PAAD	TCGA	DRHSLQSVD	DEG_APCC_DBOX_1	0.1389
p.E72K	DO46657	PAAD	ICGC	DRHSLQSVD	DEG_APCC_DBOX_1	0.1389
p.R58W	DO227549	COCA	ICGC	DRHSLQSVD	DEG_APCC_DBOX_1	0.8634
p.D65Y	DO229022	LICA	ICGC	DRHSLQSVD	DEG_APCC_DBOX_1	0.6214
p.D65Y	DO229031	LICA	ICGC	DRHSLQSVD	DEG_APCC_DBOX_1	0.6214
p.K49N	DO229041	LICA	ICGC	DRHSLQSVD	DEG_APCC_DBOX_1	0.2222
p.G74R	DO35009	PACA	ICGC	DRHSLQSVD	DEG_APCC_DBOX_1	0.0833
p.S60N	SIDM00499	Prostate Carcinoma	GDSC	DRHSLQSVD	DEG_APCC_DBOX_1	0.5958
p.S60N	ACH-000956	Prostate Cancer	CCLE	DRHSLQSVD	DEG_APCC_DBOX_1	0.5958
p.S60N	22RV1	prostate	COSMIC	DRHSLQSVD	DEG_APCC_DBOX_1	0.5958
p.G74E	ACH-001524	Skin Cancer	CCLE	DRHSLQSVD	DEG_APCC_DBOX_1	0.0833
p.W59G	SW684	soft_tissue	COSMIC	DRHSLQSVD	DEG_APCC_DBOX_1	0.7825
p.A65V	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	DRHSLQSVD	DEG_APCC_DBOX_1	0.6936
p.M61I	SNU-C2B	large_intestine	COSMIC	DRHSLQSVD	DEG_APCC_DBOX_1	0.7618
p.A74V	SNU-1040	large_intestine	COSMIC	DRHSLQSVD	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2M4	TBC1 domain family member 14	DEG_APCC_DBOX_1	57:65	DRHSLQSVD	APC,CDC20,FZR1	0.9861	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons