DegronMD - Q9P2M4(TBC1D14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G74W	TCGA-05-4396	LUAD	TCGA	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.0833
p.G74W	TCGA-05-4396	LUAD	TCGA	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation rewiring degron network	0.2222
p.G74W	DO23838	LUAD	ICGC	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.0833
p.G74W	DO23838	LUAD	ICGC	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation rewiring degron network	0.2222
p.P76Q	TCGA-66-2787	LUSC	TCGA	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation rewiring degron network	0.1667
p.P76Q	DO26647	LUSC	ICGC	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation rewiring degron network	0.1667
p.E72K	TCGA-IB-7651	PAAD	TCGA	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1389
p.E72K	TCGA-IB-7651	PAAD	TCGA	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation rewiring degron network	0.2778
p.E72K	DO46657	PAAD	ICGC	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1389
p.E72K	DO46657	PAAD	ICGC	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation rewiring degron network	0.2778
p.R58W	DO227549	COCA	ICGC	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.8634
p.D65Y	DO229022	LICA	ICGC	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.6214
p.D65Y	DO229022	LICA	ICGC	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation altering degron motif	0.7325
p.D65Y	DO229031	LICA	ICGC	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.6214
p.D65Y	DO229031	LICA	ICGC	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation altering degron motif	0.7325
p.K49N	DO229041	LICA	ICGC	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation substituting flanking lysine	0.2222
p.G74R	DO35009	PACA	ICGC	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.0833
p.G74R	DO35009	PACA	ICGC	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation rewiring degron network	0.2222
p.S60N	SIDM00499	Prostate Carcinoma	GDSC	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.5958
p.S60N	ACH-000956	Prostate Cancer	CCLE	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.5958
p.S60N	22RV1	prostate	COSMIC	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.5958
p.S66L	SIDM00837	Colorectal Carcinoma	GDSC	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation altering degron motif	0.7667
p.S66L	ACH-000958	Colon/Colorectal Cancer	CCLE	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation altering degron motif	0.7667
p.S66L	SW48	large intestine	COSMIC	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation altering degron motif	0.7667
p.T70S	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation altering degron motif	0.6005
p.T70S	ACH-000916	Lung Cancer	CCLE	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation altering degron motif	0.6005
p.T70S	NCI-H1573	lung	COSMIC	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation altering degron motif	0.6005
p.P68R	ACH-000467	Colon/Colorectal Cancer	CCLE	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation altering degron motif	0.7512
p.P68R	HCC-56	large intestine	COSMIC	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation altering degron motif	0.7512
p.P76L	ACH-001521	Skin Cancer	CCLE	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation rewiring degron network	0.1667
p.G74E	ACH-001524	Skin Cancer	CCLE	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.0833
p.G74E	ACH-001524	Skin Cancer	CCLE	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation rewiring degron network	0.2222
p.W59G	SW684	soft tissue	COSMIC	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.7825
p.A65V	SKM-1	haematopoietic and lymphoid tissue	COSMIC	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.6936
p.A65V	SKM-1	haematopoietic and lymphoid tissue	COSMIC	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation altering degron motif	0.6936
p.V70A	SK-MEL-2	skin	COSMIC	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation altering degron motif	0.6936
p.M61I	SNU-C2B	large intestine	COSMIC	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.7618
p.A74V	SNU-1040	large intestine	COSMIC	DRHSLQSVD	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.0833
p.A74V	SNU-1040	large intestine	COSMIC	DSGIPT	DEG_SCF_TRCP1_1	65:70	Mutation rewiring degron network	0.2222

Kaplan plot for TBC1D14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBC1D14

UniProt ID: Q9P2M4

Entrez ID: 57533

Protein name: TBC1 domain family member 14

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TBC1D14 in