DegronMD

Uniprot ID: Q9P2M4

Source protein: TBC1 domain family member 14

Source gene: TBC1D14

Class: DEG_SCF_TRCP1_1

Location: 65:70

E3 ligase: BTRC

DEGRON score: 0.9816

ASA_SCORE: 62.8167

COIL: 0.8712

CONS_SCORE: 0.3697

DSS_SCORE: 0.5264

HELIX: 0.0352

FCONS_SCORE: 1.0552

RIG_SCORE: 0.6704

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S66L	SIDM00837	Colorectal Carcinoma	GDSC	DSGIPT	DEG_SCF_TRCP1_1	0.7667
p.S66L	ACH-000958	Colon/Colorectal Cancer	CCLE	DSGIPT	DEG_SCF_TRCP1_1	0.7667
p.S66L	SW48	large_intestine	COSMIC	DSGIPT	DEG_SCF_TRCP1_1	0.7667
p.P68R	ACH-000467	Colon/Colorectal Cancer	CCLE	DSGIPT	DEG_SCF_TRCP1_1	0.7512
p.P68R	HCC-56	large_intestine	COSMIC	DSGIPT	DEG_SCF_TRCP1_1	0.7512
p.D65Y	DO229022	LICA	ICGC	DSGIPT	DEG_SCF_TRCP1_1	0.7325
p.D65Y	DO229031	LICA	ICGC	DSGIPT	DEG_SCF_TRCP1_1	0.7325
p.A65V	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGIPT	DEG_SCF_TRCP1_1	0.6936
p.V70A	SK-MEL-2	skin	COSMIC	DSGIPT	DEG_SCF_TRCP1_1	0.6936
p.T70S	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	DSGIPT	DEG_SCF_TRCP1_1	0.6005
p.T70S	ACH-000916	Lung Cancer	CCLE	DSGIPT	DEG_SCF_TRCP1_1	0.6005
p.T70S	NCI-H1573	lung	COSMIC	DSGIPT	DEG_SCF_TRCP1_1	0.6005
p.E72K	TCGA-IB-7651	PAAD	TCGA	DSGIPT	DEG_SCF_TRCP1_1	0.2778
p.E72K	DO46657	PAAD	ICGC	DSGIPT	DEG_SCF_TRCP1_1	0.2778
p.G74W	TCGA-05-4396	LUAD	TCGA	DSGIPT	DEG_SCF_TRCP1_1	0.2222
p.G74W	DO23838	LUAD	ICGC	DSGIPT	DEG_SCF_TRCP1_1	0.2222
p.G74R	DO35009	PACA	ICGC	DSGIPT	DEG_SCF_TRCP1_1	0.2222
p.G74E	ACH-001524	Skin Cancer	CCLE	DSGIPT	DEG_SCF_TRCP1_1	0.2222
p.A74V	SNU-1040	large_intestine	COSMIC	DSGIPT	DEG_SCF_TRCP1_1	0.2222
p.P76Q	TCGA-66-2787	LUSC	TCGA	DSGIPT	DEG_SCF_TRCP1_1	0.1667
p.P76Q	DO26647	LUSC	ICGC	DSGIPT	DEG_SCF_TRCP1_1	0.1667
p.P76L	ACH-001521	Skin Cancer	CCLE	DSGIPT	DEG_SCF_TRCP1_1	0.1667

Showing 1 to 22 of 22 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2M4	TBC1 domain family member 14	DEG_SCF_TRCP1_1	65:70	DSGIPT	BTRC	0.9816	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons