DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGIPT
Uniprot ID:
Q9P2M4
Source protein:
TBC1 domain family member 14
Source gene:
TBC1D14
Class:
DEG_SCF_TRCP1_1
Location:
65:70
E3 ligase:
BTRC
DEGRON score:
0.9816
ASA_SCORE:
62.8167
COIL:
0.8712
CONS_SCORE:
0.3697
DSS_SCORE:
0.5264
HELIX:
0.0352
FCONS_SCORE:
1.0552
RIG_SCORE:
0.6704
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G74W
TCGA-05-4396
LUAD
TCGA
DSGIPT
DEG_SCF_TRCP1_1
0.2222
p.G74W
DO23838
LUAD
ICGC
DSGIPT
DEG_SCF_TRCP1_1
0.2222
p.P76Q
TCGA-66-2787
LUSC
TCGA
DSGIPT
DEG_SCF_TRCP1_1
0.1667
p.P76Q
DO26647
LUSC
ICGC
DSGIPT
DEG_SCF_TRCP1_1
0.1667
p.E72K
TCGA-IB-7651
PAAD
TCGA
DSGIPT
DEG_SCF_TRCP1_1
0.2778
p.E72K
DO46657
PAAD
ICGC
DSGIPT
DEG_SCF_TRCP1_1
0.2778
p.D65Y
DO229022
LICA
ICGC
DSGIPT
DEG_SCF_TRCP1_1
0.7325
p.D65Y
DO229031
LICA
ICGC
DSGIPT
DEG_SCF_TRCP1_1
0.7325
p.G74R
DO35009
PACA
ICGC
DSGIPT
DEG_SCF_TRCP1_1
0.2222
p.S66L
SIDM00837
Colorectal Carcinoma
GDSC
DSGIPT
DEG_SCF_TRCP1_1
0.7667
p.S66L
ACH-000958
Colon/Colorectal Cancer
CCLE
DSGIPT
DEG_SCF_TRCP1_1
0.7667
p.S66L
SW48
large_intestine
COSMIC
DSGIPT
DEG_SCF_TRCP1_1
0.7667
p.T70S
SIDM00749
Non-Small Cell Lung Carcinoma
GDSC
DSGIPT
DEG_SCF_TRCP1_1
0.6005
p.T70S
ACH-000916
Lung Cancer
CCLE
DSGIPT
DEG_SCF_TRCP1_1
0.6005
p.T70S
NCI-H1573
lung
COSMIC
DSGIPT
DEG_SCF_TRCP1_1
0.6005
p.P68R
ACH-000467
Colon/Colorectal Cancer
CCLE
DSGIPT
DEG_SCF_TRCP1_1
0.7512
p.P68R
HCC-56
large_intestine
COSMIC
DSGIPT
DEG_SCF_TRCP1_1
0.7512
p.P76L
ACH-001521
Skin Cancer
CCLE
DSGIPT
DEG_SCF_TRCP1_1
0.1667
p.G74E
ACH-001524
Skin Cancer
CCLE
DSGIPT
DEG_SCF_TRCP1_1
0.2222
p.A65V
SKM-1
haematopoietic_and_lymphoid_tissue
COSMIC
DSGIPT
DEG_SCF_TRCP1_1
0.6936
p.V70A
SK-MEL-2
skin
COSMIC
DSGIPT
DEG_SCF_TRCP1_1
0.6936
p.A74V
SNU-1040
large_intestine
COSMIC
DSGIPT
DEG_SCF_TRCP1_1
0.2222
Drug responses associated with TBC1D14 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGIPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P2M4
TBC1 domain family member 14
DEG_SCF_TRCP1_1
65:70
DSGIPT
BTRC
0.9816
More...