DegronMD

Uniprot ID: Q5T7B8

Source protein: Kinesin-like protein KIF24

Source gene: KIF24

Class: DEG_APCC_DBOX_1

Location: 50:58

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5314

ASA_SCORE: 53.0333

COIL: 0.0156

CONS_SCORE: 0.7012

DSS_SCORE: 0.1106

HELIX: 0.983

FCONS_SCORE: 1.3562

RIG_SCORE: 0.9034

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I58M	TCGA-BH-A18V	BRCA	TCGA	DRKRLFQLI	DEG_APCC_DBOX_1	0.6507
p.I58M	DO4743	BRCA	ICGC	DRKRLFQLI	DEG_APCC_DBOX_1	0.6507
p.D50E	DO229003	COCA	ICGC	DRKRLFQLI	DEG_APCC_DBOX_1	0.5647
p.D50E	DO229505	LAML	ICGC	DRKRLFQLI	DEG_APCC_DBOX_1	0.5647
p.D50E	DO225404	LAML	ICGC	DRKRLFQLI	DEG_APCC_DBOX_1	0.5647
p.D50E	DO229047	LICA	ICGC	DRKRLFQLI	DEG_APCC_DBOX_1	0.5647
p.R51H	DO51474	PACA	ICGC	DRKRLFQLI	DEG_APCC_DBOX_1	0.8244
p.R51H	SIDM01943	Colorectal Carcinoma	GDSC	DRKRLFQLI	DEG_APCC_DBOX_1	0.8244
p.R53C	SIDM02039	Colorectal Carcinoma	GDSC	DRKRLFQLI	DEG_APCC_DBOX_1	0.719
p.R51C	SIDM00845	Burkitt's Lymphoma	GDSC	DRKRLFQLI	DEG_APCC_DBOX_1	0.8301
p.R51C	SIDM00654	Small Cell Lung Carcinoma	GDSC	DRKRLFQLI	DEG_APCC_DBOX_1	0.8301
p.R51C	SIDM00650	Small Cell Lung Carcinoma	GDSC	DRKRLFQLI	DEG_APCC_DBOX_1	0.8301
p.R51C	SIDM00971	Breast Carcinoma	GDSC	DRKRLFQLI	DEG_APCC_DBOX_1	0.8301
p.R51C	SIDM00493	Other Solid Cancers	GDSC	DRKRLFQLI	DEG_APCC_DBOX_1	0.8301
p.R51C	SIDM01681	Non-Cancerous	GDSC	DRKRLFQLI	DEG_APCC_DBOX_1	0.8301
p.I58V	SIDM00453	Pancreatic Carcinoma	GDSC	DRKRLFQLI	DEG_APCC_DBOX_1	0.5965
p.I58V	PA-TU-8988T	pancreas	COSMIC	DRKRLFQLI	DEG_APCC_DBOX_1	0.5965
p.L43V	SIDM01397	Melanoma	GDSC	DRKRLFQLI	DEG_APCC_DBOX_1	0.1389
p.L43V	ACH-000765	Skin Cancer	CCLE	DRKRLFQLI	DEG_APCC_DBOX_1	0.1389
p.I58T	ACH-001484	Leukemia	CCLE	DRKRLFQLI	DEG_APCC_DBOX_1	0.5966
p.I58T	ACH-001485	Leukemia	CCLE	DRKRLFQLI	DEG_APCC_DBOX_1	0.5966

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T7B8	Kinesin-like protein KIF24	DEG_APCC_DBOX_1	50:58	DRKRLFQLI	APC,CDC20,FZR1	0.5314	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons