DegronMD

Uniprot ID: Q08AF3

Source protein: Schlafen family member 5

Source gene: SLFN5

Class: DEG_APCC_DBOX_1

Location: 177:185

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5348

ASA_SCORE: 89.2556

COIL: 0.3972

CONS_SCORE: 0.8168

DSS_SCORE: 0.1102

HELIX: 0.447

FCONS_SCORE: 1.2281

RIG_SCORE: 0.8912

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R178I	TCGA-55-7910	LUAD	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	0.8102
p.R178I	DO23669	LUAD	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	0.8102
p.E185G	TCGA-77-6843	LUSC	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	0.6087
p.E185G	DO27588	LUSC	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	0.6087
p.R180W	TCGA-AA-A00N	COAD	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	0.7523
p.R180W	TCGA-CG-5733	STAD	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	0.7523
p.R180W	TCGA-QK-A8Z9	HNSC	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	0.7523
p.R180W	DO9876	COAD	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	0.7523
p.R180W	DO52098	HNSC	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	0.7523
p.R180W	DO38551	STAD	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	0.7523
p.R180Q	TCGA-AZ-6601	COAD	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	0.6218
p.R180Q	DO8119	COAD	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	0.6218
p.F176C	TCGA-CN-4739	HNSC	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	0.3056
p.F176C	DO14478	HNSC	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	0.3056
p.D177H	TCGA-DK-A2I4	BLCA	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	0.6577
p.D177H	DO465	BLCA	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	0.6577
p.A172D	TCGA-EO-A22R	UCEC	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	0.1944
p.A172D	DO42713	UCEC	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	0.1944
p.N188D	TCGA-VQ-AA6D	STAD	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	0.25
p.N188D	DO222392	STAD	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	0.25
p.I168K	SIDM01955	Colorectal Carcinoma	GDSC	DRKRLQYLE	DEG_APCC_DBOX_1	0.0833
p.N169Y	SIDM01955	Colorectal Carcinoma	GDSC	DRKRLQYLE	DEG_APCC_DBOX_1	0.1111
p.N169D	SIDM01608	Endometrial Carcinoma	GDSC	DRKRLQYLE	DEG_APCC_DBOX_1	0.1111
p.N169D	ACH-000990	Endometrial/Uterine Cancer	CCLE	DRKRLQYLE	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08AF3	Schlafen family member 5	DEG_APCC_DBOX_1	177:185	DRKRLQYLE	APC,CDC20,FZR1	0.5348	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons