DegronMD - Q08AF3(SLFN5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C369W	TCGA-19-5956	GBM	TCGA	FPVFSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.0833
p.C369W	DO13863	GBM	ICGC	FPVFSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.0833
p.R178I	TCGA-55-7910	LUAD	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.8102
p.R178I	DO23669	LUAD	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.8102
p.E185G	TCGA-77-6843	LUSC	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.6087
p.E185G	DO27588	LUSC	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.6087
p.R180W	TCGA-AA-A00N	COAD	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.7523
p.R180W	TCGA-CG-5733	STAD	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.7523
p.R180W	TCGA-QK-A8Z9	HNSC	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.7523
p.R180W	DO9876	COAD	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.7523
p.R180W	DO52098	HNSC	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.7523
p.R180W	DO38551	STAD	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.7523
p.R376C	TCGA-AJ-A8CT	UCEC	TCGA	FPVFSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.2778
p.R376C	DO52399	UCEC	ICGC	FPVFSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.2778
p.R376C	SIDM00232	Kidney Carcinoma	GDSC	FPVFSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.2778
p.R376C	ACH-002168	Kidney Cancer	CCLE	FPVFSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.2778
p.R376C	NCC021	kidney	COSMIC	FPVFSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.2778
p.R180Q	TCGA-AZ-6601	COAD	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.6218
p.R180Q	DO8119	COAD	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.6218
p.R376P	TCGA-B6-A0RG	BRCA	TCGA	FPVFSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.2778
p.R376P	DO2353	BRCA	ICGC	FPVFSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.2778
p.F176C	TCGA-CN-4739	HNSC	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.3056
p.F176C	DO14478	HNSC	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.3056
p.D177H	TCGA-DK-A2I4	BLCA	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.6577
p.D177H	DO465	BLCA	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation altering degron motif	0.6577
p.A172D	TCGA-EO-A22R	UCEC	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.1944
p.A172D	DO42713	UCEC	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.1944
p.P379T	TCGA-EO-A22U	UCEC	TCGA	FPVFSD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.5919
p.P379T	DO43755	UCEC	ICGC	FPVFSD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.5919
p.P379L	TCGA-HF-7132	STAD	TCGA	FPVFSD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6471
p.P379L	DO38214	STAD	ICGC	FPVFSD	LIG_APCC_ABBA_1	378:383	Mutation altering degron motif	0.6471
p.N188D	TCGA-VQ-AA6D	STAD	TCGA	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.25
p.N188D	DO222392	STAD	ICGC	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.25
p.A387V	DO8842	COAD	ICGC	FPVFSD	LIG_APCC_ABBA_1	378:383	Mutation blocking phosphorylation signal	0.6667
p.I168K	SIDM01955	Colorectal Carcinoma	GDSC	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.0833
p.N169Y	SIDM01955	Colorectal Carcinoma	GDSC	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.1111
p.S391I	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	FPVFSD	LIG_APCC_ABBA_1	378:383	Mutation rewiring degron network	0.1111
p.N169D	SIDM01608	Endometrial Carcinoma	GDSC	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.1111
p.N169D	ACH-000990	Endometrial/Uterine Cancer	CCLE	DRKRLQYLE	DEG_APCC_DBOX_1	177:185	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLFN5

UniProt ID: Q08AF3

Entrez ID: 162394

Protein name: Schlafen family member 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLFN5 in