DegronMD

Uniprot ID: Q08AF3

Source protein: Schlafen family member 5

Source gene: SLFN5

Class: LIG_APCC_ABBA_1

Location: 378:383

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5158

ASA_SCORE: 63.6667

COIL: 0.7208

CONS_SCORE: 0.7763

DSS_SCORE: 0.2121

HELIX: 0.1722

FCONS_SCORE: 1.0058

RIG_SCORE: 0.8458

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C369W	TCGA-19-5956	GBM	TCGA	FPVFSD	LIG_APCC_ABBA_1	0.0833
p.C369W	DO13863	GBM	ICGC	FPVFSD	LIG_APCC_ABBA_1	0.0833
p.R376C	TCGA-AJ-A8CT	UCEC	TCGA	FPVFSD	LIG_APCC_ABBA_1	0.2778
p.R376C	DO52399	UCEC	ICGC	FPVFSD	LIG_APCC_ABBA_1	0.2778
p.R376C	SIDM00232	Kidney Carcinoma	GDSC	FPVFSD	LIG_APCC_ABBA_1	0.2778
p.R376C	ACH-002168	Kidney Cancer	CCLE	FPVFSD	LIG_APCC_ABBA_1	0.2778
p.R376C	NCC021	kidney	COSMIC	FPVFSD	LIG_APCC_ABBA_1	0.2778
p.R376P	TCGA-B6-A0RG	BRCA	TCGA	FPVFSD	LIG_APCC_ABBA_1	0.2778
p.R376P	DO2353	BRCA	ICGC	FPVFSD	LIG_APCC_ABBA_1	0.2778
p.P379T	TCGA-EO-A22U	UCEC	TCGA	FPVFSD	LIG_APCC_ABBA_1	0.5919
p.P379T	DO43755	UCEC	ICGC	FPVFSD	LIG_APCC_ABBA_1	0.5919
p.P379L	TCGA-HF-7132	STAD	TCGA	FPVFSD	LIG_APCC_ABBA_1	0.6471
p.P379L	DO38214	STAD	ICGC	FPVFSD	LIG_APCC_ABBA_1	0.6471
p.A387V	DO8842	COAD	ICGC	FPVFSD	LIG_APCC_ABBA_1	0.6667
p.S391I	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	FPVFSD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08AF3	Schlafen family member 5	LIG_APCC_ABBA_1	378:383	FPVFSD	APC,CDC20,FZR1	0.5158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons