DegronMD

Uniprot ID: Q96KN7

Source protein: X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

Source gene: RPGRIP1

Class: CBL_PTK

Location: 167:175

E3 ligase: CBL

DEGRON score: 0.7339

ASA_SCORE: 100.6111

COIL: 0.9101

CONS_SCORE: 0.3214

DSS_SCORE: 0.7173

HELIX: 0.053

FCONS_SCORE: 1.0063

RIG_SCORE: 0.6436

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A181V	TCGA-AA-3984	COAD	TCGA	DRLSYTAPP	CBL_PTK	0.1667
p.A181V	DO9002	COAD	ICGC	DRLSYTAPP	CBL_PTK	0.1667
p.A181V	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	DRLSYTAPP	CBL_PTK	0.1667
p.A181V	ACH-000824	Esophageal Cancer	CCLE	DRLSYTAPP	CBL_PTK	0.1667
p.A181V	KYSE-510	oesophagus	COSMIC	DRLSYTAPP	CBL_PTK	0.1667
p.P174A	TCGA-DU-8166	LGG	TCGA	DRLSYTAPP	CBL_PTK	0.6392
p.P174A	DO22215	LGG	ICGC	DRLSYTAPP	CBL_PTK	0.6392
p.R168K	TCGA-MI-A75G	LIHC	TCGA	DRLSYTAPP	CBL_PTK	0.6126
p.R168K	DO49709	LIHC	ICGC	DRLSYTAPP	CBL_PTK	0.6126
p.S176L	DO228998	LICA	ICGC	DRLSYTAPP	CBL_PTK	0.3056
p.D167Y	DO229029	LICA	ICGC	DRLSYTAPP	CBL_PTK	0.7325
p.A181G	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	DRLSYTAPP	CBL_PTK	0.1667
p.D167G	ACH-000982	Colon/Colorectal Cancer	CCLE	DRLSYTAPP	CBL_PTK	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KN7	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1	CBL_PTK	167:175	DRLSYTAPP	CBL	0.7339	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons