DegronMD

Uniprot ID: O60343

Source protein: TBC1 domain family member 4

Source gene: TBC1D4

Class: DEG_APCC_DBOX_1

Location: 798:806

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8934

ASA_SCORE: 81.5889

COIL: 0.7477

CONS_SCORE: 0.2632

DSS_SCORE: 0.6277

HELIX: 0.2018

FCONS_SCORE: 0.9601

RIG_SCORE: 0.7048

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D798Y	TCGA-05-4427	LUAD	TCGA	DRNELLPLS	DEG_APCC_DBOX_1	0.6214
p.L797F	TCGA-05-4427	LUAD	TCGA	DRNELLPLS	DEG_APCC_DBOX_1	0.3056
p.P788S	TCGA-18-3409	LUSC	TCGA	DRNELLPLS	DEG_APCC_DBOX_1	0.0556
p.E814Q	TCGA-29-1777	OV	TCGA	DRNELLPLS	DEG_APCC_DBOX_1	0.1111
p.L808P	TCGA-DM-A1HB	COAD	TCGA	DRNELLPLS	DEG_APCC_DBOX_1	0.2778
p.E814D	TCGA-EO-A3B0	UCEC	TCGA	DRNELLPLS	DEG_APCC_DBOX_1	0.1111
p.P816L	TCGA-FG-A6J3	LGG	TCGA	DRNELLPLS	DEG_APCC_DBOX_1	0.0556
p.E816K	DO1780	BRCA	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.0556
p.G815E	DO10276	COAD	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.0833
p.L800P	DO52450	COCA	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.7582
p.V811I	DO229010	COCA	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.1944
p.V811I	DO229013	COCA	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.1944
p.V811I	DO229016	COCA	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.1944
p.V811I	DO229003	COCA	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.1944
p.V811I	DO229005	COCA	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.1944
p.G815V	DO14926	HNSC	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.0833
p.P808L	DO44538	LGG	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.2778
p.L795M	DO229028	LICA	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.25
p.N792K	DO229041	LICA	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.1667
p.D790Y	DO23666	LUAD	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.1111
p.L789F	DO23666	LUAD	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.5278
p.E806Q	DO28071	OV	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.6744
p.G815W	DO47442	SKCM	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.0833
p.E806D	DO219773	UCEC	ICGC	DRNELLPLS	DEG_APCC_DBOX_1	0.6758
p.P807T	SIDM00596	Endometrial Carcinoma	GDSC	DRNELLPLS	DEG_APCC_DBOX_1	0.3056
p.P807T	ACH-000941	Endometrial/Uterine Cancer	CCLE	DRNELLPLS	DEG_APCC_DBOX_1	0.3056
p.P807T	ACH-000954	Endometrial/Uterine Cancer	CCLE	DRNELLPLS	DEG_APCC_DBOX_1	0.3056
p.P807T	ACH-001517	Endometrial/Uterine Cancer	CCLE	DRNELLPLS	DEG_APCC_DBOX_1	0.3056
p.P807T	HEC-1	endometrium	COSMIC	DRNELLPLS	DEG_APCC_DBOX_1	0.3056
p.P799T	HEC-1	endometrium	COSMIC	DRNELLPLS	DEG_APCC_DBOX_1	0.7031
p.M793I	LU-165	lung	COSMIC	DRNELLPLS	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRNELLPLS

Degron related mutations and impact score

Drug responses associated with TBC1D4 mutations

All proteins holding degron of DRNELLPLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60343	TBC1 domain family member 4	DEG_APCC_DBOX_1	798:806	DRNELLPLS	APC,CDC20,FZR1	0.8934	More...