DegronMD

Uniprot ID: Q8TBZ8

Source protein: Zinc finger protein 564

Source gene: ZNF564

Class: DEG_APCC_DBOX_1

Location: 207:215

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.906

ASA_SCORE: 75.3889

COIL: 0.6163

CONS_SCORE: 0.4294

DSS_SCORE: 0.3768

HELIX: 0.1664

FCONS_SCORE: 0.5773

RIG_SCORE: 0.7715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R217I	TCGA-A5-A0G2	UCEC	TCGA	DRPSLFQIH	DEG_APCC_DBOX_1	0.2778
p.R217I	TCGA-AA-A010	COAD	TCGA	DRPSLFQIH	DEG_APCC_DBOX_1	0.2778
p.R217I	TCGA-ND-A4WC	UCS	TCGA	DRPSLFQIH	DEG_APCC_DBOX_1	0.2778
p.R217I	DO41235	UCEC	ICGC	DRPSLFQIH	DEG_APCC_DBOX_1	0.2778
p.R208H	TCGA-A5-A0G2	UCEC	TCGA	DRPSLFQIH	DEG_APCC_DBOX_1	0.8244
p.R208H	TCGA-AX-A1CE	UCEC	TCGA	DRPSLFQIH	DEG_APCC_DBOX_1	0.8244
p.R208H	DO42280	UCEC	ICGC	DRPSLFQIH	DEG_APCC_DBOX_1	0.8244
p.R208H	DO41235	UCEC	ICGC	DRPSLFQIH	DEG_APCC_DBOX_1	0.8244
p.R208H	SIDM01611	Endometrial Carcinoma	GDSC	DRPSLFQIH	DEG_APCC_DBOX_1	0.8244
p.R208H	ACH-000996	Endometrial/Uterine Cancer	CCLE	DRPSLFQIH	DEG_APCC_DBOX_1	0.8244
p.E222D	TCGA-AN-A046	BRCA	TCGA	DRPSLFQIH	DEG_APCC_DBOX_1	0.1389
p.E222D	DO1285	BRCA	ICGC	DRPSLFQIH	DEG_APCC_DBOX_1	0.1389
p.Q200K	DO229009	LICA	ICGC	DRPSLFQIH	DEG_APCC_DBOX_1	0.1389
p.S210R	DO45237	LIRI	ICGC	DRPSLFQIH	DEG_APCC_DBOX_1	0.6316

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBZ8	Zinc finger protein 564	DEG_APCC_DBOX_1	207:215	DRPSLFQIH	APC,CDC20,FZR1	0.906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons