DegronMD - Q8TBZ8(ZNF564)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P280S	TCGA-28-5214	GBM	TCGA	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.0833
p.P280S	DO14061	GBM	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.0833
p.R217I	TCGA-A5-A0G2	UCEC	TCGA	DRPSLFQIH	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.2778
p.R217I	TCGA-AA-A010	COAD	TCGA	DRPSLFQIH	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.2778
p.R217I	TCGA-ND-A4WC	UCS	TCGA	DRPSLFQIH	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.2778
p.R217I	DO41235	UCEC	ICGC	DRPSLFQIH	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.2778
p.R208H	TCGA-A5-A0G2	UCEC	TCGA	DRPSLFQIH	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.8244
p.R208H	TCGA-AX-A1CE	UCEC	TCGA	DRPSLFQIH	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.8244
p.R208H	DO42280	UCEC	ICGC	DRPSLFQIH	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.8244
p.R208H	DO41235	UCEC	ICGC	DRPSLFQIH	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.8244
p.R208H	SIDM01611	Endometrial Carcinoma	GDSC	DRPSLFQIH	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.8244
p.R208H	ACH-000996	Endometrial/Uterine Cancer	CCLE	DRPSLFQIH	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.8244
p.R264H	TCGA-A5-A2K5	UCEC	TCGA	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.8244
p.R264H	TCGA-EO-A22R	UCEC	TCGA	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.8244
p.R264H	DO233908	GACA	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.8244
p.R264H	DO42713	UCEC	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.8244
p.R264H	DO41379	UCEC	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.8244
p.E222D	TCGA-AN-A046	BRCA	TCGA	DRPSLFQIH	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1389
p.E222D	DO1285	BRCA	ICGC	DRPSLFQIH	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1389
p.F262S	TCGA-BR-4257	STAD	TCGA	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.3056
p.F262S	DO38683	STAD	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.3056
p.R273I	TCGA-E6-A1LX	UCEC	TCGA	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.2778
p.R273I	DO41020	UCEC	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.2778
p.D263E	TCGA-EE-A3J5	SKCM	TCGA	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.5647
p.D263E	DO229022	LICA	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.5647
p.D263E	DO47331	SKCM	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.5647
p.Q200K	DO229009	LICA	ICGC	DRPSLFQIH	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1389
p.S210R	DO45237	LIRI	ICGC	DRPSLFQIH	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.6316
p.K254R	DO222481	MELA	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation substituting flanking lysine	0.1944
p.G259A	DO46334	OV	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.2222
p.E257K	SIDM00789	Colorectal Carcinoma	GDSC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1667
p.E257K	ACH-000997	Colon/Colorectal Cancer	CCLE	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1667
p.E257K	HCT-15	large intestine	COSMIC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1667
p.A261T	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.2778
p.R269Q	SIDM00098	Mesothelioma	GDSC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6218
p.R269Q	H2731	pleura	COSMIC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6218
p.K279N	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation substituting flanking lysine	0.2222
p.K279N	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation substituting flanking lysine	0.2222
p.R264C	SIDM01619	Endometrial Carcinoma	GDSC	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.8301
p.R264C	ACH-000984	Endometrial/Uterine Cancer	CCLE	DRPSLFRIH	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.8301

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF564

UniProt ID: Q8TBZ8

Entrez ID: 163050

Protein name: Zinc finger protein 564

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF564 in