DegronMD

Uniprot ID: Q8TBZ8

Source protein: Zinc finger protein 564

Source gene: ZNF564

Class: DEG_APCC_DBOX_1

Location: 263:271

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9972

ASA_SCORE: 77.4667

COIL: 0.7244

CONS_SCORE: 0.4536

DSS_SCORE: 0.3966

HELIX: 0.1249

FCONS_SCORE: 0.6973

RIG_SCORE: 0.7681

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P280S	TCGA-28-5214	GBM	TCGA	DRPSLFRIH	DEG_APCC_DBOX_1	0.0833
p.P280S	DO14061	GBM	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	0.0833
p.R264H	TCGA-A5-A2K5	UCEC	TCGA	DRPSLFRIH	DEG_APCC_DBOX_1	0.8244
p.R264H	TCGA-EO-A22R	UCEC	TCGA	DRPSLFRIH	DEG_APCC_DBOX_1	0.8244
p.R264H	DO233908	GACA	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	0.8244
p.R264H	DO42713	UCEC	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	0.8244
p.R264H	DO41379	UCEC	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	0.8244
p.F262S	TCGA-BR-4257	STAD	TCGA	DRPSLFRIH	DEG_APCC_DBOX_1	0.3056
p.F262S	DO38683	STAD	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	0.3056
p.R273I	TCGA-E6-A1LX	UCEC	TCGA	DRPSLFRIH	DEG_APCC_DBOX_1	0.2778
p.R273I	DO41020	UCEC	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	0.2778
p.D263E	TCGA-EE-A3J5	SKCM	TCGA	DRPSLFRIH	DEG_APCC_DBOX_1	0.5647
p.D263E	DO229022	LICA	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	0.5647
p.D263E	DO47331	SKCM	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	0.5647
p.K254R	DO222481	MELA	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	0.1944
p.G259A	DO46334	OV	ICGC	DRPSLFRIH	DEG_APCC_DBOX_1	0.2222
p.E257K	SIDM00789	Colorectal Carcinoma	GDSC	DRPSLFRIH	DEG_APCC_DBOX_1	0.1667
p.E257K	ACH-000997	Colon/Colorectal Cancer	CCLE	DRPSLFRIH	DEG_APCC_DBOX_1	0.1667
p.E257K	HCT-15	large_intestine	COSMIC	DRPSLFRIH	DEG_APCC_DBOX_1	0.1667
p.A261T	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	DRPSLFRIH	DEG_APCC_DBOX_1	0.2778
p.R269Q	SIDM00098	Mesothelioma	GDSC	DRPSLFRIH	DEG_APCC_DBOX_1	0.6218
p.R269Q	H2731	pleura	COSMIC	DRPSLFRIH	DEG_APCC_DBOX_1	0.6218
p.K279N	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	DRPSLFRIH	DEG_APCC_DBOX_1	0.2222
p.K279N	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	DRPSLFRIH	DEG_APCC_DBOX_1	0.2222
p.R264C	SIDM01619	Endometrial Carcinoma	GDSC	DRPSLFRIH	DEG_APCC_DBOX_1	0.8301
p.R264C	ACH-000984	Endometrial/Uterine Cancer	CCLE	DRPSLFRIH	DEG_APCC_DBOX_1	0.8301

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRPSLFRIH

Degron related mutations and impact score

Drug responses associated with ZNF564 mutations

All proteins holding degron of DRPSLFRIH

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBZ8	Zinc finger protein 564	DEG_APCC_DBOX_1	263:271	DRPSLFRIH	APC,CDC20,FZR1	0.9972	More...