DegronMD

Uniprot ID: Q9Y6D5

Source protein: Brefeldin A-inhibited guanine nucleotide-exchange protein 2

Source gene: ARFGEF2

Class: DEG_APCC_DBOX_1

Location: 1508:1516

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8285

ASA_SCORE: 88.3556

COIL: 0.7534

CONS_SCORE: 0.2289

DSS_SCORE: 0.6038

HELIX: 0.2066

FCONS_SCORE: 0.978

RIG_SCORE: 0.6807

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1520C	TCGA-AO-A03M	BRCA	TCGA	DRQSLSSID	DEG_APCC_DBOX_1	0.6667
p.S1520C	TCGA-F7-A624	HNSC	TCGA	DRQSLSSID	DEG_APCC_DBOX_1	0.6667
p.S1520C	DO2216	BRCA	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	0.6667
p.S1520C	DO44440	HNSC	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	0.6667
p.P1519L	TCGA-DA-A1HV	SKCM	TCGA	DRQSLSSID	DEG_APCC_DBOX_1	0.25
p.P1519L	DO37659	SKCM	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	0.25
p.P1519S	TCGA-EB-A97M	SKCM	TCGA	DRQSLSSID	DEG_APCC_DBOX_1	0.25
p.P1519S	DO50298	SKCM	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	0.25
p.P1519S	ACH-001567	Skin Cancer	CCLE	DRQSLSSID	DEG_APCC_DBOX_1	0.25
p.P1519H	TCGA-EE-A181	SKCM	TCGA	DRQSLSSID	DEG_APCC_DBOX_1	0.25
p.P1519H	DO37444	SKCM	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	0.25
p.V1505L	DO228948	LICA	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	0.25
p.Q1510H	DO229006	LICA	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	0.647
p.G1523R	DO230940	LUSC	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	0.1389
p.G1523R	DO224584	LUSC	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	0.1389
p.D1504N	SIDM00719	Small Cell Lung Carcinoma	GDSC	DRQSLSSID	DEG_APCC_DBOX_1	0.2222
p.D1504N	NCI-H345	lung	COSMIC	DRQSLSSID	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6D5	Brefeldin A-inhibited guanine nucleotide-exchange protein 2	DEG_APCC_DBOX_1	1508:1516	DRQSLSSID	APC,CDC20,FZR1	0.8285	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons