DegronMD - Q9Y6D5(ARFGEF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A270T	TCGA-2H-A9GK	ESCA	TCGA	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.A270T	TCGA-AP-A051	UCEC	TCGA	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.A270T	TCGA-AX-A0J1	UCEC	TCGA	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.A270T	TCGA-B5-A3FC	UCEC	TCGA	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.A270T	TCGA-D5-6930	COAD	TCGA	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.A270T	DO10550	COAD	ICGC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.A270T	DO233764	GACA	ICGC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.A270T	DO41871	UCEC	ICGC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.A270T	DO41199	UCEC	ICGC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.A270T	DO42673	UCEC	ICGC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.A270T	SIDM00980	Gastric Carcinoma	GDSC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.A270T	ACH-000948	Gastric Cancer	CCLE	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.A270T	23132-87	stomach	COSMIC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.S1520C	TCGA-AO-A03M	BRCA	TCGA	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation blocking phosphorylation signal	0.6667
p.S1520C	TCGA-F7-A624	HNSC	TCGA	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation blocking phosphorylation signal	0.6667
p.S1520C	DO2216	BRCA	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation blocking phosphorylation signal	0.6667
p.S1520C	DO44440	HNSC	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation blocking phosphorylation signal	0.6667
p.R257M	TCGA-B5-A11E	UCEC	TCGA	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.2778
p.R257M	DO229022	LICA	ICGC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.2778
p.R257M	DO41644	UCEC	ICGC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.2778
p.E273K	TCGA-D8-A27G	BRCA	TCGA	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1111
p.E273K	DO5465	BRCA	ICGC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1111
p.P1519L	TCGA-DA-A1HV	SKCM	TCGA	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation rewiring degron network	0.25
p.P1519L	DO37659	SKCM	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation rewiring degron network	0.25
p.P1519S	TCGA-EB-A97M	SKCM	TCGA	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation rewiring degron network	0.25
p.P1519S	DO50298	SKCM	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation rewiring degron network	0.25
p.P1519S	ACH-001567	Skin Cancer	CCLE	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation rewiring degron network	0.25
p.P1519H	TCGA-EE-A181	SKCM	TCGA	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation rewiring degron network	0.25
p.P1519H	DO37444	SKCM	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation rewiring degron network	0.25
p.R257S	TCGA-NJ-A4YQ	LUAD	TCGA	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.2778
p.R257S	DO218944	LUAD	ICGC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.2778
p.R274S	TCGA-Q1-A73Q	CESC	TCGA	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.0833
p.R274S	DO51613	CESC	ICGC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.0833
p.V1505L	DO228948	LICA	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation rewiring degron network	0.25
p.A256S	DO229026	LICA	ICGC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.25
p.G253C	DO229045	LICA	ICGC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1667
p.Q1510H	DO229006	LICA	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation altering degron motif	0.647
p.G1523R	DO230940	LUSC	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation rewiring degron network	0.1389
p.G1523R	DO224584	LUSC	ICGC	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation rewiring degron network	0.1389
p.R257K	SIDM00648	Small Cell Lung Carcinoma	GDSC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.2778
p.R257K	NCI-H1304	lung	COSMIC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.2778
p.P271A	SIDM01638	Non-Cancerous	GDSC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1667
p.P271A	SIDM01161	Other Sarcomas	GDSC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1667
p.P271A	SIDM00172	Head and Neck Carcinoma	GDSC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1667
p.P271A	SIDM00049	Colorectal Carcinoma	GDSC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1667
p.P271A	SIDM01567	Hodgkin's Lymphoma	GDSC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1667
p.P271A	SIDM01757	Bladder Carcinoma	GDSC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1667
p.D1504N	SIDM00719	Small Cell Lung Carcinoma	GDSC	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation rewiring degron network	0.2222
p.D1504N	NCI-H345	lung	COSMIC	DRQSLSSID	DEG_APCC_DBOX_1	1508:1516	Mutation rewiring degron network	0.2222
p.T251A	SIDM00901	Endometrial Carcinoma	GDSC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1111
p.T251A	ACH-000940	Endometrial/Uterine Cancer	CCLE	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1111
p.T251A	AN3-CA	endometrium	COSMIC	DSGKVST	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1111

Kaplan plot for ARFGEF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARFGEF2

UniProt ID: Q9Y6D5

Entrez ID: 10564

Protein name: Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARFGEF2 in