DegronMD

Uniprot ID: Q9Y6D5

Source protein: Brefeldin A-inhibited guanine nucleotide-exchange protein 2

Source gene: ARFGEF2

Class: DEG_SCF_TRCP1_1

Location: 259:265

E3 ligase: BTRC

DEGRON score: 0.9676

ASA_SCORE: 71.3571

COIL: 0.7546

CONS_SCORE: 0.2151

DSS_SCORE: 0.751

HELIX: 0.0791

FCONS_SCORE: 0.9813

RIG_SCORE: 0.5854

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A270T	TCGA-2H-A9GK	ESCA	TCGA	DSGKVST	DEG_SCF_TRCP1_1	0.1944
p.A270T	TCGA-AP-A051	UCEC	TCGA	DSGKVST	DEG_SCF_TRCP1_1	0.1944
p.A270T	TCGA-AX-A0J1	UCEC	TCGA	DSGKVST	DEG_SCF_TRCP1_1	0.1944
p.A270T	TCGA-B5-A3FC	UCEC	TCGA	DSGKVST	DEG_SCF_TRCP1_1	0.1944
p.A270T	TCGA-D5-6930	COAD	TCGA	DSGKVST	DEG_SCF_TRCP1_1	0.1944
p.A270T	DO10550	COAD	ICGC	DSGKVST	DEG_SCF_TRCP1_1	0.1944
p.A270T	DO233764	GACA	ICGC	DSGKVST	DEG_SCF_TRCP1_1	0.1944
p.A270T	DO41871	UCEC	ICGC	DSGKVST	DEG_SCF_TRCP1_1	0.1944
p.A270T	DO41199	UCEC	ICGC	DSGKVST	DEG_SCF_TRCP1_1	0.1944
p.A270T	DO42673	UCEC	ICGC	DSGKVST	DEG_SCF_TRCP1_1	0.1944
p.A270T	SIDM00980	Gastric Carcinoma	GDSC	DSGKVST	DEG_SCF_TRCP1_1	0.1944
p.A270T	ACH-000948	Gastric Cancer	CCLE	DSGKVST	DEG_SCF_TRCP1_1	0.1944
p.A270T	23132-87	stomach	COSMIC	DSGKVST	DEG_SCF_TRCP1_1	0.1944
p.R257M	TCGA-B5-A11E	UCEC	TCGA	DSGKVST	DEG_SCF_TRCP1_1	0.2778
p.R257M	DO229022	LICA	ICGC	DSGKVST	DEG_SCF_TRCP1_1	0.2778
p.R257M	DO41644	UCEC	ICGC	DSGKVST	DEG_SCF_TRCP1_1	0.2778
p.E273K	TCGA-D8-A27G	BRCA	TCGA	DSGKVST	DEG_SCF_TRCP1_1	0.1111
p.E273K	DO5465	BRCA	ICGC	DSGKVST	DEG_SCF_TRCP1_1	0.1111
p.R257S	TCGA-NJ-A4YQ	LUAD	TCGA	DSGKVST	DEG_SCF_TRCP1_1	0.2778
p.R257S	DO218944	LUAD	ICGC	DSGKVST	DEG_SCF_TRCP1_1	0.2778
p.R274S	TCGA-Q1-A73Q	CESC	TCGA	DSGKVST	DEG_SCF_TRCP1_1	0.0833
p.R274S	DO51613	CESC	ICGC	DSGKVST	DEG_SCF_TRCP1_1	0.0833
p.A256S	DO229026	LICA	ICGC	DSGKVST	DEG_SCF_TRCP1_1	0.25
p.G253C	DO229045	LICA	ICGC	DSGKVST	DEG_SCF_TRCP1_1	0.1667
p.R257K	SIDM00648	Small Cell Lung Carcinoma	GDSC	DSGKVST	DEG_SCF_TRCP1_1	0.2778
p.R257K	NCI-H1304	lung	COSMIC	DSGKVST	DEG_SCF_TRCP1_1	0.2778
p.P271A	SIDM01638	Non-Cancerous	GDSC	DSGKVST	DEG_SCF_TRCP1_1	0.1667
p.P271A	SIDM01161	Other Sarcomas	GDSC	DSGKVST	DEG_SCF_TRCP1_1	0.1667
p.P271A	SIDM00172	Head and Neck Carcinoma	GDSC	DSGKVST	DEG_SCF_TRCP1_1	0.1667
p.P271A	SIDM00049	Colorectal Carcinoma	GDSC	DSGKVST	DEG_SCF_TRCP1_1	0.1667
p.P271A	SIDM01567	Hodgkin's Lymphoma	GDSC	DSGKVST	DEG_SCF_TRCP1_1	0.1667
p.P271A	SIDM01757	Bladder Carcinoma	GDSC	DSGKVST	DEG_SCF_TRCP1_1	0.1667
p.T251A	SIDM00901	Endometrial Carcinoma	GDSC	DSGKVST	DEG_SCF_TRCP1_1	0.1111
p.T251A	ACH-000940	Endometrial/Uterine Cancer	CCLE	DSGKVST	DEG_SCF_TRCP1_1	0.1111
p.T251A	AN3-CA	endometrium	COSMIC	DSGKVST	DEG_SCF_TRCP1_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGKVST

Degron related mutations and impact score

Drug responses associated with ARFGEF2 mutations

All proteins holding degron of DSGKVST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6D5	Brefeldin A-inhibited guanine nucleotide-exchange protein 2	DEG_SCF_TRCP1_1	259:265	DSGKVST	BTRC	0.9676	More...