DegronMD

Uniprot ID: Q9P2T0

Source protein: Testicular haploid expressed gene protein

Source gene: THEG

Class: DEG_APCC_DBOX_1

Location: 353:361

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9285

ASA_SCORE: 72.8222

COIL: 0.7759

CONS_SCORE: 0.5199

DSS_SCORE: 0.6144

HELIX: 0.1534

FCONS_SCORE: 1.0015

RIG_SCORE: 0.6701

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A358T	TCGA-21-1071	LUSC	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	0.6028
p.A358T	SIDM00418	Thyroid Gland Carcinoma	GDSC	DRRPLASMS	DEG_APCC_DBOX_1	0.6028
p.A358T	SIDM00217	Colorectal Carcinoma	GDSC	DRRPLASMS	DEG_APCC_DBOX_1	0.6028
p.A358T	ACH-000716	Thyroid Cancer	CCLE	DRRPLASMS	DEG_APCC_DBOX_1	0.6028
p.A358T	ACH-000999	Colon/Colorectal Cancer	CCLE	DRRPLASMS	DEG_APCC_DBOX_1	0.6028
p.A358T	SNU-1040	large_intestine	COSMIC	DRRPLASMS	DEG_APCC_DBOX_1	0.6028
p.A358T	TT2609-C02	thyroid	COSMIC	DRRPLASMS	DEG_APCC_DBOX_1	0.6028
p.L362M	TCGA-86-8669	LUAD	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	0.3056
p.M360I	TCGA-AA-3947	COAD	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	0.6507
p.R345C	TCGA-AZ-4315	COAD	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	0.1111
p.R355H	TCGA-B5-A11Y	UCEC	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	0.7133
p.R355H	TCGA-EO-A22U	UCEC	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	0.7133
p.A367T	TCGA-BR-4362	STAD	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	0.1667
p.S359F	TCGA-CQ-5331	HNSC	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	0.6871
p.P356S	TCGA-GF-A6C9	SKCM	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	0.5641
p.S359C	TCGA-K4-A54R	BLCA	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	0.643
p.R355C	TCGA-L5-A43C	ESCA	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	0.719
p.D349H	DO2870	BRCA	ICGC	DRRPLASMS	DEG_APCC_DBOX_1	0.2222
p.P353H	DO23332	LINC	ICGC	DRRPLASMS	DEG_APCC_DBOX_1	0.7694
p.D349N	DO219503	SKCM	ICGC	DRRPLASMS	DEG_APCC_DBOX_1	0.2222
p.A343T	DO38336	STAD	ICGC	DRRPLASMS	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2T0	Testicular haploid expressed gene protein	DEG_APCC_DBOX_1	353:361	DRRPLASMS	APC,CDC20,FZR1	0.9285	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons