DegronMD - Q9P2T0(THEG)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A358T	TCGA-21-1071	LUSC	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation altering degron motif	0.6028
p.A358T	SIDM00418	Thyroid Gland Carcinoma	GDSC	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation altering degron motif	0.6028
p.A358T	SIDM00217	Colorectal Carcinoma	GDSC	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation altering degron motif	0.6028
p.A358T	ACH-000716	Thyroid Cancer	CCLE	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation altering degron motif	0.6028
p.A358T	ACH-000999	Colon/Colorectal Cancer	CCLE	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation altering degron motif	0.6028
p.A358T	SNU-1040	large intestine	COSMIC	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation altering degron motif	0.6028
p.A358T	TT2609-C02	thyroid	COSMIC	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation altering degron motif	0.6028
p.L362M	TCGA-86-8669	LUAD	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation rewiring degron network	0.3056
p.M360I	TCGA-AA-3947	COAD	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation altering degron motif	0.6507
p.R345C	TCGA-AZ-4315	COAD	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation rewiring degron network	0.1111
p.R355H	TCGA-B5-A11Y	UCEC	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation altering degron motif	0.7133
p.R355H	TCGA-EO-A22U	UCEC	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation altering degron motif	0.7133
p.A367T	TCGA-BR-4362	STAD	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation rewiring degron network	0.1667
p.S359F	TCGA-CQ-5331	HNSC	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation altering degron motif	0.6871
p.M116I	TCGA-EO-A22X	UCEC	TCGA	RRRRLMELA	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1111
p.M116I	DO222654	ESCA	ICGC	RRRRLMELA	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1111
p.M116I	DO43907	UCEC	ICGC	RRRRLMELA	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1111
p.P356S	TCGA-GF-A6C9	SKCM	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation altering degron motif	0.5641
p.S359C	TCGA-K4-A54R	BLCA	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation altering degron motif	0.643
p.R355C	TCGA-L5-A43C	ESCA	TCGA	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation altering degron motif	0.719
p.D349H	DO2870	BRCA	ICGC	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation rewiring degron network	0.2222
p.P353H	DO23332	LINC	ICGC	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation altering degron motif	0.7694
p.K135N	DO230961	LUSC	ICGC	RRRRLMELA	DEG_APCC_DBOX_1	124:132	Mutation substituting flanking lysine	0.3611
p.K135N	DO224594	LUSC	ICGC	RRRRLMELA	DEG_APCC_DBOX_1	124:132	Mutation substituting flanking lysine	0.3611
p.K135N	DO232761	PBCA	ICGC	RRRRLMELA	DEG_APCC_DBOX_1	124:132	Mutation substituting flanking lysine	0.3611
p.D349N	DO219503	SKCM	ICGC	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation rewiring degron network	0.2222
p.A343T	DO38336	STAD	ICGC	DRRPLASMS	DEG_APCC_DBOX_1	353:361	Mutation substituting flanking lysine	0.1667
p.R123K	SIDM00557	Neuroblastoma	GDSC	RRRRLMELA	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.3056
p.R123K	KP-N-RT-BM-1	autonomic ganglia	COSMIC	RRRRLMELA	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.3056
p.L131R	SIDM00042	Pancreatic Carcinoma	GDSC	RRRRLMELA	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.8428
p.L131R	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRRRLMELA	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.8428
p.T127M	EGI-1	biliary tract	COSMIC	RRRRLMELA	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.7423
p.P116L	MEL-JUSO	skin	COSMIC	RRRRLMELA	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

THEG

UniProt ID: Q9P2T0

Entrez ID: 51298

Protein name: Testicular haploid expressed gene protein (Cancer/testis antigen 56) (CT56)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for THEG in