DegronMD

Uniprot ID: Q9P2T0

Source protein: Testicular haploid expressed gene protein

Source gene: THEG

Class: DEG_APCC_DBOX_1

Location: 124:132

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8448

ASA_SCORE: 97.3

COIL: 0.4826

CONS_SCORE: 0.6088

DSS_SCORE: 0.4687

HELIX: 0.4824

FCONS_SCORE: 1.5137

RIG_SCORE: 0.8013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M116I	TCGA-EO-A22X	UCEC	TCGA	RRRRLMELA	DEG_APCC_DBOX_1	0.1111
p.M116I	DO222654	ESCA	ICGC	RRRRLMELA	DEG_APCC_DBOX_1	0.1111
p.M116I	DO43907	UCEC	ICGC	RRRRLMELA	DEG_APCC_DBOX_1	0.1111
p.K135N	DO230961	LUSC	ICGC	RRRRLMELA	DEG_APCC_DBOX_1	0.3611
p.K135N	DO224594	LUSC	ICGC	RRRRLMELA	DEG_APCC_DBOX_1	0.3611
p.K135N	DO232761	PBCA	ICGC	RRRRLMELA	DEG_APCC_DBOX_1	0.3611
p.R123K	SIDM00557	Neuroblastoma	GDSC	RRRRLMELA	DEG_APCC_DBOX_1	0.3056
p.R123K	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	RRRRLMELA	DEG_APCC_DBOX_1	0.3056
p.L131R	SIDM00042	Pancreatic Carcinoma	GDSC	RRRRLMELA	DEG_APCC_DBOX_1	0.8428
p.L131R	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRRRLMELA	DEG_APCC_DBOX_1	0.8428
p.T127M	EGI-1	biliary_tract	COSMIC	RRRRLMELA	DEG_APCC_DBOX_1	0.7423
p.P116L	MEL-JUSO	skin	COSMIC	RRRRLMELA	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2T0	Testicular haploid expressed gene protein	DEG_APCC_DBOX_1	124:132	RRRRLMELA	APC,CDC20,FZR1	0.8448	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons