DegronMD

Uniprot ID: Q4V328

Source protein: GRIP1-associated protein 1

Source gene: GRIPAP1

Class: DEG_APCC_DBOX_1

Location: 769:777

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6471

ASA_SCORE: 79.4667

COIL: 0.5353

CONS_SCORE: 0.4293

DSS_SCORE: 0.3863

HELIX: 0.4271

FCONS_SCORE: 0.9663

RIG_SCORE: 0.7003

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V776I	TCGA-32-2616	GBM	TCGA	DRSGLGSVL	DEG_APCC_DBOX_1	0.5965
p.D779Y	TCGA-99-7458	LUAD	TCGA	DRSGLGSVL	DEG_APCC_DBOX_1	0.2778
p.E786D	TCGA-BS-A0UF	UCEC	TCGA	DRSGLGSVL	DEG_APCC_DBOX_1	0.0833
p.H779Q	DO229015	LICA	ICGC	DRSGLGSVL	DEG_APCC_DBOX_1	0.2778
p.E770D	DO42568	UCEC	ICGC	DRSGLGSVL	DEG_APCC_DBOX_1	0.6758
p.T759I	SNU-1040	large_intestine	COSMIC	DRSGLGSVL	DEG_APCC_DBOX_1	0.0556
p.S772F	LIM1215	large_intestine	COSMIC	DRSGLGSVL	DEG_APCC_DBOX_1	0.7982
p.T773I	SNU-1040	large_intestine	COSMIC	DRSGLGSVL	DEG_APCC_DBOX_1	0.7078
p.E759G	SNU-C2B	large_intestine	COSMIC	DRSGLGSVL	DEG_APCC_DBOX_1	0.0556
p.S786F	LIM1215	large_intestine	COSMIC	DRSGLGSVL	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4V328	GRIP1-associated protein 1	DEG_APCC_DBOX_1	769:777	DRSGLGSVL	APC,CDC20,FZR1	0.6471	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons