DegronMD - Q4V328(GRIPAP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V776I	TCGA-32-2616	GBM	TCGA	DRSGLGSVL	DEG_APCC_DBOX_1	769:777	Mutation altering degron motif	0.5965
p.D779Y	TCGA-99-7458	LUAD	TCGA	DRSGLGSVL	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.2778
p.E261D	TCGA-A5-A0G1	UCEC	TCGA	KETLFND	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1667
p.E261D	DO42472	UCEC	ICGC	KETLFND	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1667
p.E786D	TCGA-BS-A0UF	UCEC	TCGA	DRSGLGSVL	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.0833
p.L263I	DO223059	ESCA	ICGC	KETLFND	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1111
p.H779Q	DO229015	LICA	ICGC	DRSGLGSVL	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.2778
p.L252M	DO229038	LICA	ICGC	KETLFND	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.5999
p.E770D	DO42568	UCEC	ICGC	DRSGLGSVL	DEG_APCC_DBOX_1	769:777	Mutation altering degron motif	0.6758
p.K249N	ACH-000974	Endometrial/Uterine Cancer	CCLE	KETLFND	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.6918
p.T759I	SNU-1040	large intestine	COSMIC	DRSGLGSVL	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.0556
p.S772F	LIM1215	large intestine	COSMIC	DRSGLGSVL	DEG_APCC_DBOX_1	769:777	Mutation altering degron motif	0.7982
p.T773I	SNU-1040	large intestine	COSMIC	DRSGLGSVL	DEG_APCC_DBOX_1	769:777	Mutation altering degron motif	0.7078
p.E759G	SNU-C2B	large intestine	COSMIC	DRSGLGSVL	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.0556
p.S786F	LIM1215	large intestine	COSMIC	DRSGLGSVL	DEG_APCC_DBOX_1	769:777	Mutation rewiring degron network	0.0833

Kaplan plot for GRIPAP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRIPAP1

UniProt ID: Q4V328

Entrez ID: 56850

Protein name: GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GRIPAP1 in