DegronMD

Uniprot ID: Q4V328

Source protein: GRIP1-associated protein 1

Source gene: GRIPAP1

Class: LIG_APCC_ABBAyCdc20_2

Location: 249:255

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5167

ASA_SCORE: 101.0143

COIL: 0.1477

CONS_SCORE: 0.4233

DSS_SCORE: 0.401

HELIX: 0.8514

FCONS_SCORE: 1.0279

RIG_SCORE: 0.7693

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E261D	TCGA-A5-A0G1	UCEC	TCGA	KETLFND	LIG_APCC_ABBAyCdc20_2	0.1667
p.E261D	DO42472	UCEC	ICGC	KETLFND	LIG_APCC_ABBAyCdc20_2	0.1667
p.L263I	DO223059	ESCA	ICGC	KETLFND	LIG_APCC_ABBAyCdc20_2	0.1111
p.L252M	DO229038	LICA	ICGC	KETLFND	LIG_APCC_ABBAyCdc20_2	0.5999
p.K249N	ACH-000974	Endometrial/Uterine Cancer	CCLE	KETLFND	LIG_APCC_ABBAyCdc20_2	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4V328	GRIP1-associated protein 1	LIG_APCC_ABBAyCdc20_2	249:255	KETLFND	APC,CDC20,FZR1	0.5167	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons