DegronMD

Uniprot ID: Q5T2T1

Source protein: MAGUK p55 subfamily member 7

Source gene: MPP7

Class: DEG_APCC_DBOX_1

Location: 174:182

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7497

ASA_SCORE: 55.4111

COIL: 0.6709

CONS_SCORE: 0.579

DSS_SCORE: 0.3256

HELIX: 0.1823

FCONS_SCORE: 1.0636

RIG_SCORE: 0.7357

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N189S	TCGA-58-A46L	LUSC	TCGA	DRSGLIHVG	DEG_APCC_DBOX_1	0.1389
p.G182C	TCGA-AP-A051	UCEC	TCGA	DRSGLIHVG	DEG_APCC_DBOX_1	0.6489
p.H180Y	TCGA-CN-A6V7	HNSC	TCGA	DRSGLIHVG	DEG_APCC_DBOX_1	0.6118
p.E187K	TCGA-D3-A8GI	SKCM	TCGA	DRSGLIHVG	DEG_APCC_DBOX_1	0.1944
p.E184K	TCGA-GN-A269	SKCM	TCGA	DRSGLIHVG	DEG_APCC_DBOX_1	0.2778
p.R177Q	DO51607	CESC	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	0.7329
p.K186N	DO8264	COAD	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	0.2222
p.H167N	DO228909	LICA	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	0.1389
p.E170K	DO220877	MELA	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	0.2222
p.E170K	DO229456	SKCA	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	0.2222
p.R171S	DO32217	OV	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	0.25
p.R171K	DO37406	SKCM	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	0.25
p.P164L	DO48702	SKCM	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	0.0556
p.S192L	DO51301	SKCM	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	0.0556
p.Q169H	DO38177	SKCM	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	0.1944
p.Q169L	DO38232	STAD	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	0.1944
p.V187I	DO43971	UCEC	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	0.1944
p.I191M	SIDM00217	Colorectal Carcinoma	GDSC	DRSGLIHVG	DEG_APCC_DBOX_1	0.0833
p.I191M	ACH-000999	Colon/Colorectal Cancer	CCLE	DRSGLIHVG	DEG_APCC_DBOX_1	0.0833
p.I191M	SNU-1040	large_intestine	COSMIC	DRSGLIHVG	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T2T1	MAGUK p55 subfamily member 7	DEG_APCC_DBOX_1	174:182	DRSGLIHVG	APC,CDC20,FZR1	0.7497	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons