DegronMD - Q5T2T1(MPP7)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N189S	TCGA-58-A46L	LUSC	TCGA	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.1389
p.R362Q	TCGA-A8-A07U	BRCA	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.1111
p.R362Q	TCGA-FW-A3R5	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.1111
p.R362Q	SIDM01483	Melanoma	GDSC	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.1111
p.R362Q	ACH-000582	Skin Cancer	CCLE	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.1111
p.R362Q	COLO-741	large intestine	COSMIC	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.1111
p.G182C	TCGA-AP-A051	UCEC	TCGA	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation altering degron motif	0.6489
p.R361Q	TCGA-AP-A0LM	UCEC	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.1389
p.R361Q	TCGA-AX-A05S	UCEC	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.1389
p.K335T	TCGA-AP-A1E0	UCEC	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation substituting flanking lysine	0.2222
p.T333A	TCGA-B5-A3FA	UCEC	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.0556
p.Y360C	TCGA-BA-A6DG	HNSC	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.1667
p.D347N	TCGA-BF-AAP2	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation altering degron motif	0.6932
p.D347N	TCGA-DA-A1I1	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation altering degron motif	0.6932
p.A349T	TCGA-BR-7851	STAD	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation altering degron motif	0.6028
p.H180Y	TCGA-CN-A6V7	HNSC	TCGA	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation altering degron motif	0.6118
p.S336F	TCGA-D3-A2JH	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.1389
p.E187K	TCGA-D3-A8GI	SKCM	TCGA	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.1944
p.E355K	TCGA-D9-A6EC	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.3056
p.E355K	TCGA-DA-A1IC	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.3056
p.E355K	TCGA-EB-A44O	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.3056
p.E355K	TCGA-F1-6177	STAD	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.3056
p.P359S	TCGA-EE-A2GC	SKCM	TCGA	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.1944
p.E184K	TCGA-GN-A269	SKCM	TCGA	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.2778
p.R177Q	DO51607	CESC	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation altering degron motif	0.7329
p.K186N	DO8264	COAD	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.2222
p.N363H	DO8264	COAD	ICGC	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.0833
p.H167N	DO228909	LICA	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.1389
p.E170K	DO220877	MELA	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.2222
p.E170K	DO229456	SKCA	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.2222
p.R171S	DO32217	OV	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.25
p.P351S	DO37861	SKCM	ICGC	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation altering degron motif	0.6752
p.R171K	DO37406	SKCM	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.25
p.P164L	DO48702	SKCM	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.0556
p.S192L	DO51301	SKCM	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.0556
p.Q169H	DO38177	SKCM	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.1944
p.Q169L	DO38232	STAD	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.1944
p.V355I	DO229234	THCA	ICGC	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.3056
p.A354G	DO41199	UCEC	ICGC	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation altering degron motif	0.754
p.V187I	DO43971	UCEC	ICGC	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.1944
p.Y338C	SIDM01045	Endometrial Carcinoma	GDSC	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.1944
p.Y338C	ACH-000978	Endometrial/Uterine Cancer	CCLE	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.1944
p.Y338C	EN	endometrium	COSMIC	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation rewiring degron network	0.1944
p.I191M	SIDM00217	Colorectal Carcinoma	GDSC	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.0833
p.I191M	ACH-000999	Colon/Colorectal Cancer	CCLE	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.0833
p.I191M	SNU-1040	large intestine	COSMIC	DRSGLIHVG	DEG_APCC_DBOX_1	174:182	Mutation rewiring degron network	0.0833
p.D350G	SIDM01608	Endometrial Carcinoma	GDSC	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation altering degron motif	0.6087
p.D350G	ACH-000990	Endometrial/Uterine Cancer	CCLE	SDQYDTADVPTY	DEG_COP1_1	343:354	Mutation altering degron motif	0.6087

Kaplan plot for MPP7 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MPP7

UniProt ID: Q5T2T1

Entrez ID: 143098

Protein name: MAGUK p55 subfamily member 7

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MPP7 in